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Chemodex
Curcumin
54
CHF
CHF 54.00
In stock
CDX-C0158-G01010 gCHF 54.00
CDX-C0158-G05050 gCHF 177.00
| Product Details | |
|---|---|
| Synonyms | (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Diferuloylmethane; Diferulylmethane; Diferuloylmethane; Natural Yellow 3 |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H20O6 |
| MW | 368.38 |
| CAS | 458-37-7 |
| RTECS | MI5230000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥95% |
| Appearance | Yellow to orange solid. |
| Solubility | Soluble in DMSO (25mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| Smiles | OC1=CC=C(/C=C/C(CC(/C=C/C2=CC(OC)=C(O)C=C2)=O)=O)C=C1OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4), tumorigenesis and development (Shh, Gli), metabolism (PPARγ, Nrf2), epigenetics (HDACs, HATs, DNA methyltransferase I and microRNAs) and inflammation (NLRP3, TLR4, NF-κB, TNF, IL-6, IL-1, COX-2 and 5-LOX).
Product References
(1) R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006) (Review) | (2) V.P. Menon & A.R. Sudheer; Adv. Exp. Med. Biol. 595, 105 (2007) (Review) | (3) G. Kuttan, et al.; Adv. Exp. Med. Biol. 595, 173 (2007) (Review) | (4) B.B. Aggarwal & K.B. Harikumar; Int. J. Biochem. Cell Biol. 41, 40 (2009) (Review) | (5) S. Fu & R. Kurzrock; Cancer 116, 4670 (2010) (Review) | (6) L. Alappat & A.B. Awad; Nutr. Rev. 68, 729 (2010) (Review) | (7) R.B. Mythri & M.M. Bharath; Curr. Pharm. Des. 18, 91 (2012) (Review) | (8) A.A. Momtazi, et al.; Rev. Physiol. Biochem. Pharmacol. 171, 1 (2016) (Review) | (9) S.S. Soflaei, et al.; Curr. Pharm. Des. 24, 123 (2018) (Review) | (10) M. Boozari, et al.; J. Cell Physiol. 234, 12471 (2019) (Review) | (11) K.R. Kahkhaie, et al.; Inflammopharmacol. 27, 885 (2019) (Review) | (12) D.J.Den Hartogh, et al.; Nutrients 12, 118 (2020) (Review) | (13) D.J.Den Hartogh, et al.; Nutrients 12, 58 (2020) (Review) | (14) M.A. Panaro, et al.; Int. J. Mol. Sci. 21, 2299 (2020) (Review) | (15) M.R. Jennings & R.J. Parks; Viruses 12, 1242 (2020) (Review) | (16) A.Saeedi-Boroujeni, et al.; Basic. Clin. Pharmacol. Toxicol. 128, 37 (2021) (Review)