Caroverin

Specifications / Handling

More Information
Product Details
Synonyms	1-[2-(Diethylamino)ethyl]-3-(p-methoxybenzyl)-2-quinoxalone; Spadon; Spasmium
Product Type	Chemical
Properties
Formula	C₂₂H₂₇N₃O₂
MW	365.47
CAS	23465-76-1
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥99% (HPLC)
Appearance	White or slightly yellow, fine powder.
Solubility	Soluble in DMSO (10 mg/ml). Insolube in water.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	MSPRUJDUTKRMLM-UHFFFAOYSA-N
Smiles	O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Quinoxaline compound, originally developed as a spasmolytic drug. Acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. Antioxidant agent through partial prevention of the formation and the highly active scavenging of hydroxyl radicals. Used to treat inner ear diseases such as tinnitus. Shown to inhibit tumor-promoting factors and potentially useful as a chemotherapeutic agent.

Product References

(1) Y. Ishida, et al., Br. J. Pharmacol. 71, 343 (1980) | (2) B. Saletu, et al.; Arzneimittelforsch. 45, 217 (1995) | (3) D.M. Denk, et al.; Acta Otolaryngol. 117, 825 (1997) | (4) H. Nohl, et al.; Biofactors 19, 79 (2003) | (5) G. Haymerle, et al.; Eur. Arch. Otorhinolaryngol. 272, 3451 (2015)

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