1-(4'-Carboxybutyl)-3,7-dimethylxanthine

Specifications / Handling

More Information
Product Details
Synonyms	2,3,6,7-Tetrahydro-3,7-dimethyl-2,6-dioxo-1H-purine-1-pentanoic acid DB-dmx
Product Type	Chemical
Properties
Formula	C₁₂H₁₆N₄O₄
MW	280.28
CAS	38975-44-9
Source/Host Chemicals	Synthetic
Purity Chemicals	≥97% (HPLC)
Appearance	White powder.
Solubility	Soluble in ethyl acetate.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	JDMFPLGXRUJOTC-UHFFFAOYSA-N
Smiles	CN1C=NC2=C1C(=O)N(CCCCC(O)=O)C(=O)N2C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Pentoxifylline (PTX) metabolite. Can be used as reference material. Showed platelet aggregation in whole blood in vitro. Shown to be more effective than PTX in protecting WC/1 murine fibrosarcoma cells from TNF-α cytotoxicity and in inhibiting neutrophil superoxide anion production, degranulation (lactoferrin release) and surface expression of the β-2 integrin CD11b/CD18.

Product References

(1) S. Hayashi, et al.; Chem. Pharm. Bull. 24, 1384 (1976) | (2) T.A. Bryce, et al.; J. Chromatogr. 344, 397 (1985) | (3) G.W. Sullivan, et al.; Infect. Immun. 56, 1722 (1988) | (4) M. Fantin, et al.; Eur. J. Pharmacol. 301, 535 (2006) | (5) M. Magnusson, et al.; Eur. J. Pharmacol. 290, 581 (2008)

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