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Chemodex
Cordycepin
54
CHF
CHF 54.00
In stock
CDX-C0339-M01010 mgCHF 54.00
CDX-C0339-M02525 mgCHF 129.00
CDX-C0339-M100100 mgCHF 366.00
| Product Details | |
|---|---|
| Synonyms | 3'-Deoxyadenosine; NSC 63984; NSC 401022; 9-Cordyceposidoadenine; BRN 0035194 |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H13N5O3 |
| MW | 251.24 |
| CAS | 73-03-0 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water, ethanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | OFEZSBMBBKLLBJ-BAJZRUMYSA-N |
| Smiles | OC[C@@H]1C[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Cordycepin is a nucleoside (adenosine analog) antibiotic that acts as a polyadenylation inhibitor when converted to 3’-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce poly(A) tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3β/β-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
Product References
(1) G.G. Lovinger, et al.; Virology 55, 524 (1973) | (2) R.I. Gumport, et al.; Biochemistry 15, 2804 (1976) | (3) A.M. Sugar & R.P. McCaffrey; Antimicrob. Agents Chemother. 42, 1424 (1998) | (4) E.N. Kodama, et al.; Biochem. Pharmacol. 59, 273 (2000) | (5) L.S. Chen, et al.; Br. J. Haematol. 140, 682 (2008) | (6) Y.Y. Wong, et al.; J. Biol. Chem. 285, 2610 (2010) | (7) H.J. Lee, et al.; Invest. New Drugs 30, 1917 (2012) | (8) B.S. Ko, et al.; PLoS One 8, e76320 (2013) | (9) H.S. Tuli, et al.; Life Sci. 93, 863 (2013) (Review) | (10) C. Wu, et al.; J. Cell Mol. Med. 18, 293 (2014) | (11) K. Nakamura, et al.; J. Pharmacol. Sci. 127, 53 (2015) (Review) | (12) Y. Li, et al.; Oncol. Lett. 9, 2541 (2015) | (13) J. Yang, et al.; Biomed. Pharmacother. 95, 1777 (2017) | (14) Y. Wang, et al.; Exp. Ther. Med. 14, 3067 (2017)
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