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Chemodex
Celecoxib
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| Product Details | |
|---|---|
| Synonyms | 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; SC 58635; YM 177 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H14F3N3O2S |
| MW | 381.37 |
| CAS | 169590-42-5 |
| RTECS | DB2944937 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to beige powder. |
| Solubility | Soluble in DMSO (15mg/ml), DMF (25mg/ml) or ethanol (25mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| Smiles | O=S(=O)(N)C1=CC=C(C=C1)N2N=C(C=C2C=3C=CC(=CC3)C)C(F)(F)F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) and a highly selective cyclooxygenase-2 (COX-2) inhibitor. By preferentially inhibiting COX-2 over COX-1, celecoxib suppresses the formation of pro-inflammatory prostaglandins while minimizing effects on gastric COX-1 activity. It is widely used as a pharmacological tool in inflammation, pain, cancer, and cardiovascular research. In addition to its well-established anti-inflammatory mechanism, celecoxib has been shown to exert COX-2-independent biological effects, including induction of apoptosis, modulation of Bcl-2 family proteins, and regulation of ion channel activity. These properties make celecoxib a widely used research tool in inflammation, oncology, and cell-death signaling studies.
Product References
[1] M.M. Goldenberg; Clin. Ther. 21, 1497 (1999) (Review) | [2] N.M. Davies, et al.; Clin. Pharmacokinet. 38, 225 (2000) (Review) | [3] D. Clemett & K.L. Goa; Drugs 59, 957 (2000) (Review) | [4] I.A. Mardini & G.A. Fitzgerald; Mol. Interv. 1, 30 (2001) | [5] A.T. Koki & J.L. Masferrer; Cancer Control 9, 28 (2002) (Review) | [6] V. Jendrossek, et al.; FASEB J. 17, 1547 (2003) | [7] K. Kismet, et al.; Cancer Detect. Prev. 28, 127 (2004) (Review) | [8] D. Jiang, et al.;Int. J. Mol. Sci. 11, 4106 (2010) | [9] K. Antoniou, et al.; Expert Opin. Pharmacother. 8, 1719 (2007) (Review) | [10] L.L. Winfield & F. Payton-Stewart; Future Med. Chem. 4, 361 (2012) (Review) | [11] V. Jendrossek; Cancer Lett. 332, 313 (2013) (Review) | [12] R.V. Frolov & S. Singh; Eur. J. Pharmacol. 730, 61 (2014) (Review) | [13] A.F. Khafaga, et al.; Nanomedicine 16, 1691 (2021) (Review)