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Chemodex
Corilagin
177
CHF
CHF 177.00
In stock
CDX-C0650-M01010 mgCHF 177.00
CDX-C0650-M05050 mgCHF 530.00
| Product Details | |
|---|---|
| Synonyms | 1-O-Galloyl-3,6-hexahydroxydiphenol-β-D-Glucopyranose |
| Product Type | Chemical |
| Properties | |
| Formula | C27H22O18 |
| MW | 634.45 |
| CAS | 23094-69-1 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO, DMF or ethanol (all 20mg/ml). Slightly soluble in water (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | TUSDEZXZIZRFGC-XIGLUPEJSA-N |
| Smiles | O=C(O[C@H]([C@H]1O)[C@H](O)[C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC3=O)C4=CC(O)=C(O)C(O)=C4C5=C3C=C(O)C(O)=C5O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants. It inhibits squalene epoxidase, a key enzyme in cholesterol synthesis and has various anti-inflammatory and anti-cancer effects. This compound displays the ability to inhibit NF-κB pathway activation and also prevent the release of TNF-α. Additional studies show that Corilagin significantly inhibits type 1 plasminogen activator inhibitor (PAI-1) in rat plasma. Shown to have antioxidant, antiviral and hepatoprotective properties. Induces apoptosis, autophagy and ROS generation in several cell lines.
Product References
(1) I. Abe, et al.; J. Nat. Prod. 64, 1010 (2001) | (2) S. Okabe, et al.; Biol. Pharm. Bull. 24, 1145 (2001) | (3) Z.Q. Shen, et al.; Planta Med. 69, 1109 (2003) | (4) S. Shiota, et al.; Microbiol. Immunol. 48, 67 (2004) | (5) S. Kinoshita, et al.; Phytomedicine 14, 755 (2007) | (6) X.R. Dong, et al.; Int. J. Mol. Med. 25, 531 (2010) | (7) R. Gambari, et al.; Intern. Immunopharmacol. 13, 308 (2012) | (8) H.T. Xiao, et al.; J. Nat. Prod. 76, 2120 (2013) | (9) L. Jia, et al.; BMC Complement. Altern. Med. 13, 33 (2013) | (10) R. Gambari, et al.; Phytother. Res. 28, 781 (2014) | (11) H.R. Li, et al.; BMC Complement. Altern. Med. 17, 18 (2017) | (12) B.U. Reddy, et al.; Antiviral Res. 150, 47 (2018) | (13) X. Li, et al.; Biomed. Pharmacother. 99, 43 (2018) (Review) | (14) J. Xu, et al.; Int. J. Mol. Med. 43, 967 (2019) | (15) H.S. Nandini & P.R. Naik; Chem. Biol. Interact. 299, 186 (2019)