Chemodex

Dibucaine hydrochloride

CHF 34.00
In stock
CDX-C0693-G0011 gCHF 34.00
CDX-C0693-G0055 gCHF 102.00
CDX-C0693-G02525 gCHF 305.00
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Product Details
Synonyms Cinchocaine hydrochloride; 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
Product Type Chemical
Properties
Formula C20H29N3O2 . HCl
MW 343.4 . 36.5
CAS 61-12-1
RTECS GD3325000
Source/Host Chemicals Synthetic
Purity Chemicals ≥99% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in water (50mg/ml), DMSO (50mg/ml) or ethanol (50mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key IVHBBMHQKZBJEU-UHFFFAOYSA-N
Smiles O=C(NCCN(CC)CC)C1=CC(OCCCC)=NC2=CC=CC=C21.Cl
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.

Product References

(1) G.R. Padmanabhan, et al.; Anal. Profiles Drug Subs. 12, 105 (1983) | (2) A Seelig; Biochim. Biophys. Acta 899, 196 (1987) | (3) E. Garcia-Martin & C. Gutierrez-Merino; J. Neurochem. 54, 1238 (1990) | (4) B.K. Stringer & H.J. Harmon; Biochem. Pharmacol. 40, 1077 (1990) | (5) A. Oda, et al.; Am. J. Physiol. 269, C118 (1995) | (6) Y. Kuroda, et al.; Biophys. J. 71, 1191 (1996) | (7) M. Kim, et al.; Exp. Cell Res. 231, 235 (1997) | (8) M. Kansha, et al.; Anesthesiology 91, 1798 (1999) | (9) K. Arita, et al.; Biochem. Pharmacol. 60, 905 (2000) | (10) T. Souto-Padron, et al.; Parasitol. Res. 99, 317 (2006) | (11) W. Zhang, et al.; Int. J. Mol. Sci. 12, 2125 (2011) | (12) H.A. Douglas, et al.; J. Neurophysiol. 105, 1482 (2011) | (13) R. Ulferts, et al.; Antimicrob. Agents Chemother. 60, 2627 (2016)

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