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Chemodex
Clomiphene citrate
34
CHF
CHF 34.00
In stock
CDX-C0696-G0011 gCHF 34.00
CDX-C0696-G0055 gCHF 122.00
| Product Details | |
|---|---|
| Synonyms | Clomifene; Omifin; NSC 35770; 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine; Clomiphene citrate salt |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H28ClNO . C6H8O7 |
| MW | 598.08 |
| CAS | 50-41-9 |
| RTECS | YE0875000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMOS or DMF. Slightly soluble in water, methanol or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PYTMYKVIJXPNBD-BTKVJIOYSA-N |
| Smiles | Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(C(O)=O)(O)CC(O)=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17β-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.
Product References
(1) J.H. Clark & B.M. Markaverich; Pharmacol. Ther. 15, 467 (1981) | (2) E.Y. Adashi; Fertil. Steril. 42, 331 (1984) | (3) E. Kousta, et al.; Hum. Reprod. Update 3, 359 (1997) | (4) G.G.J.M. Kuiper, et al.; Endocrinology 138, 863 (1997) | (5) T. Hayon, et al.; Anticancer Res. 19, 2089 (1999) | (6) S.G. Haskell; South Med. J. 96, 469 (2003) | (7) R. Homburg; Hum. Reprod. 20, 2043 (2005) | (8) M. Amita, et al.; Endocrinology 151, 394 (2010)