Corosolic acid

Specifications / Handling

More Information
Product Details
Synonyms	(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid; 2α-Hydroxyursolic acid; Colosolic acid; Corsolic acid; Glucosol
Product Type	Chemical
Properties
Formula	C₃₀H₄₈O₄
MW	472.7
CAS	4547-24-4
Source/Host Chemicals	Plant
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white powder.
Solubility	Soluble in DMSO (10mg/ml) or methanol (1 mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	HFGSQOYIOKBQOW-LNGPDNCPSA-N
Smiles	CC1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)C(O)C[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])[C@H]1C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Corosolic acid is a triterpene phytochemical found in medicinal herbal extracts. It possesses antiatherosclerotic, antihyperlipidemic/antidiabetic, antioxidant, anti-inflammatory, antifungal, antiviral and antitumor activities. It is an apoptotic agent that induces caspase-8, -9 and -3 activation and shows antiproliferative effects against cancer cell lines. It stimulates glucose uptake via enhancing insulin receptor phosphorylation and ameliorates obesity in vivo. It has been shown to exhibit antiangiogenic and antilymphangiogenic effects in vitro and in vivo. Has also been shown to inhibit mitochondrial fission and NOX2 expression preventing NLRP3 inflammasome activation. It inhibits adipose tissue inflammation and ameliorate insulin resistance via AMPK activation and is an α-glucosidase inhibitor.

Product References

(1) K.S Ahn, et al.; Planta Med. 64, 468 (1998) | (2) T. Miura, et al.; Biol. Pharm. Bull. 29, 585 (2006) | (3) L. Shi, et al.; Eur. J. Pharmacol. 584, 21 (2008) | (4) K. Yamada, et al.; Biol. Pharm. Bull. 31, 651 (2008) | (5) Y. Xu, et al.; Cancer Lett. 284, 229 (2009) | (6) H. Horlad, et al.; Mol. Nutr. Food Res. 57, 1046 (2013) | (7) K.H. Yoo, et al.; Phytother. Res. 29, 714 (2015) | (8) S.J. Kim, et al.; BMB Rep. 49, 276 (2016) | (9) Y. Li, et al.; Antioxid. Redox Signal. 24, 893 (2016) | (10) J. Yang, et al.; Phytomedicine 23, 181 (2016) | (11) M. Ni, et al.; J. Sci. Food Agric. 99, 5881 (2019)

Call	+41 61 926 6040
Fax	+41 61 926 6049