Dansylcadaverine

CHF 96.00
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CDX-D0189-M250250 mgCHF 96.00
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Product Details
Synonyms N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide; N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine; MDC; Monodansyl cadaverine
Product Type Chemical
Properties
Formula

C17H25N3O2S

MW 335.46
CAS 10121-91-2
Source/Host Chemicals Synthetic.
Purity Chemicals ≥90% (HPLC)
Appearance Off-white solid.
Solubility Soluble in methanol or DMSO.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key MLEBFEHOJICQQS-UHFFFAOYSA-N
Smiles CN(C)C1=C(C=CC=C2S(NCCCCCN)(=O)=O)C2=CC=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Fluorescent probe for derivatization of aldehydes, ketones and carboxylic acids. Used to prepare small fluorescent biomolecules via amidation or reductive amination. Used to monitor autophagy. Functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. Accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. Has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles. Fluorescent substrate for assaying transamidating enzymes. Shown to inhibit endocytosis, the fibrin-stabilizing factor and epidermal growth factor (EGF) internalization. Dansyl dyes have environmentally sensitive fluorescence quantum yields and emission maxima along with large stokes shifts. Spectral Data: λex 335nm; λem518 nm in methanol.

Product References

(1) L. Lorand, et al.; Anal. Biochem. 93, 453 (1979) | (2) H.T. Haigler, et al.; J. Biol. Chem. 255, 1239 (1980) | (3) R.R. Hantgan; Biochemistry 21, 1821 (1982) | (4) E. Perez-Paya, et al.; FEBS Lett. 278, 51 (1991) | (5) C.M. Gomez, et al.; Int. J. Biol. Macromol. 27, 291 (2000) | (6) D.B. Munafo & M.I. Colombo; J Cell Sci. 114, 3619 (2001) | (7) A. Campisi, et al.; Brain. Res. 978, 24 (2003) | (8) Y. Deguchi, et al.; Neurochem. 84, 1154 (2003) | (9) R.W. Sabnis; Handbook of biological dyes and stains (2010)

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