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Chemodex
Dioscin
231
CHF
CHF 231.00
In stock
CDX-D0195-M02525 mgCHF 231.00
| Product Details | |
|---|---|
| Synonyms | Collettiside III; Polyphyllin III; CCRIS 4123 |
| Product Type | Chemical |
| Properties | |
| Formula |
C45H72O16 |
| MW | 869.04 |
| CAS | 19057-60-4 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Wthie to off-white powder. |
| Solubility | Soluble in DMSO (10mg/ml), DMF (10mg/ml) or ethanol (5mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VNONINPVFQTJOC-ZGXDEBHDSA-N |
| Smiles | C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O[C@H](O[C@@H]7CO)[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Dioscin is a natural steroid saponin originally isolated from plants used in herbal remedies. It has anticancer, anti-inflammatory, immunoregulatory, antioxidant, hyoplipidemic, antiviral, neuroprotective and antifungal activities. It inhibits proliferation, induces autophagy and oxygen-mediated apoptosis in cancer cells. It has been shown to inhibit colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK pathways. It inhibits adipogenesis through the AMPK/MAPK pathway. Dioscin showed protective effect against liver fibrosis by potently inhibiting ITGA5. Promotes proliferation of pancreatic beta cells via Wnt/β-catenin signaling pathways. It has been shown inhibit the nuclear transport of NF-κ and the expression of reactive oxygen species (ROS) and consequently the expression of inflammasome targets such as NLRP3. Potent inhibitor of Skp2, component of the ubiquitin/proteasome degradation pathway.
Product References
(1) J. Cai, et al.; Biol. Pharm. Bull. 25, 193 (2002) | (2) Z. Wang, et al.; Cancer Biol. Ther. 13, 138 (2012) | (3) J. cho, et al.; Biochim. Biophys. Acta. 1828, 1153 (2013) | (4) M.J. Hsieh, et al.; Arch. Toxicol. 87, 1927 (2013) | (5) L. Lv, et al.; Food Chem. Toxicol. 59, 657 (2013) | (6) B. Poudel, et al.; Int. J. Mol. Med. 34, 1401 (2014) | (7) S. Wu, et al.; Biochimie 110, 62 (2015) | (8) M. Liu, et al.; Sci. Rep. 5, 7973 (2015) | (9) L. Xu, et al.; Food Chem. Toxicol. 107, 318 (2017) | (10) F. Yu, et al.; Clin. Lab. 64, 785 (2018) | (11) X. Tao, et al.; Pharmacol. Res. 137, 259 (2018) (Review) | (12) Y. Qi, et al.; Molecules 24, E1247 (2019) | (13) L. Yang, et al.; Biomed. Res. Int. 2019, 5763602 (2019) (Review) | (14) W. Yin, et al.; Small 16, e1905977 (2020) | (15) W. Jiang, et al.; EBioMedicine 51, 102593 (2020)