4'-Diethylamino-3-hydroxyflavone

CHF 204.00
In stock
CDX-D0202-M05050 mgCHF 204.00
CDX-D0202-M100100 mgCHF 353.00
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Product Details
Synonyms DEAHF; FE; DHF; DMHF
Product Type Chemical
Properties
Formula

C19H19NO3

MW 309.36
CAS 146680-78-6
Source/Host Chemicals Synthetic.
Purity Chemicals ≥90% (NMR)
Appearance Yellow powder.
Solubility Soluble in DMSO, ethanol, methanol or acetonitrile.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key NTRKEYLXTPNPIY-UHFFFAOYSA-N
Smiles O=C1C2=C(C=CC=C2)OC(C3=CC=C(N(CC)CC)C=C3)=C1O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Fluorescent dye that exhibits dual band fluorescence emission which is sensitive to environmental factors. One band originates from the normal excited state (N*) and the other is due to the excited state intramolecular proton transfer (ESPIT) reaction product tautomer (T*). An increase in solvent polarity and hydrogen bonding ability of the solvent leads to an increase in the population of the N* form relative to the T* form. The intensity ratio of the normal and tautomeric fluorescence bands are near 510nm and 570nm, with a main absorption band (370-420nm). There exists a latent third emission band peaked at 535nm, which is reliably recorded upon excitation at wavelengths of 470-500nm. The positions of the two bands, as well as their intensity ratios are sensitive to the local environment, making many of these compounds attractive ratiometric fluorescent sensors. Attaching such fluorophores covalently to peptides and proteins, peptide-membrane interactions and structural changes of proteins can be studied. Furthermore, this dye may have important future applications as fluorescent sensors for the detection of adenosine triphosphate (ATP), as their excitation spectra are sensitive to ATP and this effect is selective over other nucleotides.

Product References

(1) A. Sytnik, et al.; PNAS 91, 11968 (1994) | (2) Y.-M. Cheng, et al.; J. Phys. Chem. A 109, 11696 (2005) | (3) V.G. Pivorenko, et al.; J. Fluoresc. 16, 9 (2006) | (4) V.I. Tomin & R. Jaworski; Opt. Spectrosc. 109, 279 (2010) | (5) Y. Kimura, et al.; J. Phys. Chem. B 114, 11847 (2010) | (6) K. Hino, et al.; Bull. Chem. Soc. Jpn. 86, 721 (2013) | (7) D. Gosh, et al.; J. Phys. Chem. B 119, 5650 (2015) | (8) Z. Szakacs, et al.; Photochem. Photobiol. Sci. 15, 219 (2016) | (9) K. Furukawa, et al.; Chem. Phys. Lett. 643, 109 (2016)

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