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Chemodex
Dansyl fluoride
68
CHF
CHF 68.00
In stock
CDX-D0241-M250250 mgCHF 68.00
| Product Details | |
|---|---|
| Synonyms | 5-(Dimethylamino)-1-naphthalenesulfonyl fluoride; DNSF |
| Product Type | Chemical |
| Properties | |
| Formula |
C12H12FNO2S |
| MW | 253.3 |
| CAS | 34523-28-9 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in chloroform or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | JMHHECQPPFEVMU-UHFFFAOYSA-N |
| Smiles | CN(C)C1=C(C=CC=C2S(=O)(F)=O)C2=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Dansyl fluoride is a fluorogenic reagent used as a specific fluorescent probe for serine proteases and is a serine-type protease inhibitor. It is an active site directed fluorescent inhibitor of guanidinobenzoatase (GB), which binds to both the colonic isoenzymic forms of the GB. The GB on cell surfaces after binding dansyl fluoride makes the cells fluoresce blue. It has been used for the location of tumour cells in frozen sections of human lung squamous cell carcinoma and colonic carcinoma tissues. It is used as a precursor for the synthesis of other derivatives like dansyl amide. Spectral data: λex 360nm; λem 580nm (methanol).
Product References
(1) W.L Vaz & G. Schoellmann; Biochim. Biophys. Acta 439, 194 (1976) | (2) J. Stackhouse & F.H. Westheimer; J. Org. Chem. 46, 1891 (1981) | (3) G. Schoellmann, et al.; Biochim. Biophys. Acta 704, 403 (1982) | (4) R.F. Chen & C.H. Scott; Anal. Lett. 18, 393 (1985) | (5) M. Anees & E.W. Benbow; J. Enzyme Inhib. 10, 195 (1996) | (6) R. Zhou, et al.; PNAS 95, 4959 (1998)