(S)-O-Desmethylnaproxen

CHF 153.00
In stock
CDX-D0390-M01010 mgCHF 153.00
CDX-D0390-M05050 mgCHF 612.00
More Information
Product Details
Synonyms (S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid; (S)-6-O-Desmethylnaproxen
Product Type Chemical
Properties
Formula C13H12O3
MW 216.2
CAS 52079-10-4
Source/Host Chemicals Synthetic.
Purity Chemicals ≥97% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in chloroform.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key XWJUDDGELKXYNO-QMMMGPOBSA-N
Smiles C[C@H](C(O)=O)C1=CC2=CC=C(O)C=C2C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.

Product References

(1) C.H. Kiang, et al.; Drug Metab. Dispos. 17, 43 (1989) | (2) A. Rettie, et al.; Chem. Res. Toxicol. 5, 54 (1992) | (3) T.B. Vree, et al.; Br. J. Clin. Pharmacol. 35, 467 (1993) | (4) T.B. Vree, et al.; Biopharm. Drug Dispos. 14, 491 (1993) | (5) P. Bonnabry, et al.; Eur. J. Clin. Pharmacol. 49, 305 (1996) | (6) J.O. Miners, et al.; Biochem. Pharmacol. 51, 1003 (1996) | (7) T.S. Tracy, et al.; Eur. J. Clin. Pharmacol. 52, 293 (1997) | (8) S. Rao, et al.; J. Med. Chem. 43, 2789 (2000) | (9) L. Wei, et al.; Mol. Pharmacol. 72, 1280 (2007) | (10) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010)

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