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Chemodex
(S)-O-Desmethylnaproxen
162
CHF
CHF 162.00
In stock
CDX-D0390-M01010 mgCHF 162.00
CDX-D0390-M05050 mgCHF 651.00
| Product Details | |
|---|---|
| Synonyms | (S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid; (S)-6-O-Desmethylnaproxen |
| Product Type | Chemical |
| Properties | |
| Formula | C13H12O3 |
| MW | 216.2 |
| CAS | 52079-10-4 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in chloroform. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XWJUDDGELKXYNO-QMMMGPOBSA-N |
| Smiles | C[C@H](C(O)=O)C1=CC2=CC=C(O)C=C2C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.
Product References
(1) C.H. Kiang, et al.; Drug Metab. Dispos. 17, 43 (1989) | (2) A. Rettie, et al.; Chem. Res. Toxicol. 5, 54 (1992) | (3) T.B. Vree, et al.; Br. J. Clin. Pharmacol. 35, 467 (1993) | (4) T.B. Vree, et al.; Biopharm. Drug Dispos. 14, 491 (1993) | (5) P. Bonnabry, et al.; Eur. J. Clin. Pharmacol. 49, 305 (1996) | (6) J.O. Miners, et al.; Biochem. Pharmacol. 51, 1003 (1996) | (7) T.S. Tracy, et al.; Eur. J. Clin. Pharmacol. 52, 293 (1997) | (8) S. Rao, et al.; J. Med. Chem. 43, 2789 (2000) | (9) L. Wei, et al.; Mol. Pharmacol. 72, 1280 (2007) | (10) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010)