Difluoromethyl phenyl sulfone

CHF 96.00
In stock
CDX-D0401-GG252.5 gCHF 96.00
CDX-D0401-G01010 gCHF 281.00
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Product Details
Synonyms Phenyl difluoromethyl sulfone
Product Type Chemical
Properties
Formula C7H6F2O2S
MW 192.2
CAS 1535-65-5
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (HPLC)
Appearance Colorless to light yellow semi-solid or solid.
Solubility Soluble in chloroform.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key LRHDNAVPELLXDL-UHFFFAOYSA-N
Smiles FC(F)S(=O)(=O)C1=CC=CC=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of α-difluoromethyl amines, anti-difluoropropanediols, β-difluoromethylated and β-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.

Product References

(1) G.K.S. Prakash, et al.; J. Org. Chem. 68, 4457 (2003) | (2) G.K.S. Prakash, et al.; Angew. Chem. 42, 5216 (2003) | (3) G.K.S. Prakash, et al.; Angew. Chem. 43, 5203 (2004) | (4) G.K.S. Prakash, et al.; Org. Lett. 6, 4315 (2004) | (5) Y. Li & J. Hu; Angew. Chem. 44, 5882 (2005) | (6) G.K.S. Prakash, et al.; Europ. J. Org. Chem. 11, 2218 (2005) | (7) C. Ni, et al.; Angew. Chem. 46, 786 (2007) | (8) J. Liu, et al.; J. Org. Chem. 72, 3119 (2007) | (9) C. Ni, et al.; J. Org. Chem. 73, 5699 (2008) | (10) M. Hu, et al.; J. Fluor. Chem. 155, 52 (2013)

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