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Chemodex
Dichlone
As low as
58
CHF
CHF 58.00
In stock
Only %1 left
CDX-D0641-M100100 mgCHF 58.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | 2,3-Dichloro-1,4-naphthoquinone; CNQ; Dichlon; NSC 537; USR 604 |
| Product Type | Chemical |
| Properties | |
| Formula | C10H4Cl2O2 |
| MW | 227.04 |
| CAS | 117-80-6 |
| RTECS | QL7525000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (GC) |
| Appearance | White to light yellow powder. |
| Solubility | Soluble in chloroform or DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | SVPKNMBRVBMTLB-UHFFFAOYSA-N |
| Smiles | ClC1=C(Cl)C(=O)c2ccccc2C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 6 months after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Dichlone is a naphthoquinone derivative and is widely used in various applications, particularly as a pesticide (fungicide and algicide). This compound can be used as an analytical reference. Dichlone shows several biological properties. It is a potent redox mediator, inducing oxidative stress, has been shown to inhibit ryanodine receptors and acts as a potent DNA methylation inhibitor (EC50=460nM against Dnmt3A/3L catalytic complex). Dichlone is also used as an organic catalyst or as chemical intermediate for synthetic procedures (dyes, pigments) or for spectrophotometric analysis of primary aliphatic amines.
Product-specific References
(1) A.A. Abou-Ouf, et al.; J. Pharm. Sci. 62, 1700 (1973) | (2) H.C. Sikka, et al.; Chem. Biol. Interact. 9, 261 (1974) | (3) C.A. Pritsos, et al.; Arch. Biochem. Biophys. 217, 98 (1982) | (4) F.A. El-Yazbi, et al.; J. Pharm. Biomed. Anal. 19, 819 (1999) | (5) C. Morisseau, et al.; Environ Health Perspect. 117, 1867 (2009) | (6) P.P. Vaughan, et al.; Photochem. Photobiol. 86, 1327 (2010) | (7) A. Ceccaldi, et al.; ACS Chem. Biol. 8, 543 (2013) | (8) T.S. Belal, et al.; Spectrochim. Acta A Mol. Biomol. Spectrosc. 155, 47 (2016) | (9) A.A. Petrova, et al.; FEBS Lett. 592, 2220 (2018)