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Chemodex
Enalaprilat
162
CHF
CHF 162.00
In stock
CDX-E0090-M05050 mgCHF 162.00
CDX-E0090-M250250 mgCHF 489.00
| Product Details | |
|---|---|
| Synonyms | EAL; Enalapril acid; MK-422 |
| Product Type | Chemical |
| Properties | |
| Formula | C18H24N2O5 |
| MW | 348.4 |
| CAS | 76420-72-9 |
| RTECS | TW3590600 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White solid. |
| Solubility | Slightly soluble in water. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
| Smiles | C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Active metabolite enalapril. Nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Shown to improve cardiac preservation via bradykinin receptor and PKC without affecting ATP metabolism. Has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway. Increases PPARβ/δ expression, without influence on PPARα and PPARγ.
Product References
(1) D.J. DiPette, et al.; Clin. Pharmacol. Ther. 38, 199 (1985) | (2) J.G. Kelly & K. O'Malley; Clin. Pharmacokinet. 19, 177 (1990) | (3) X. Yang, et al.; J. Mol. Cell Cardiol. 28, 1445 (1996) | (4) R. Lupi, et al.; Eur. J. Endocrinol. 154, 355 (2006) | (5) M. Yu, et al.; Molecules 17, 2738 (2012) | (6) H. Cernecka, et al.; Eur. J. Pharmacol. 714, 472 (2013)