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Chemodex
Entecavir monohydrate
95
CHF
CHF 95.00
In stock
CDX-E0229-M05050 mgCHF 95.00
CDX-E0229-M200200 mgCHF 285.00
| Product Details | |
|---|---|
| Synonyms | Baraclude; BMS 200475; SQ 34,676; 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate |
| Product Type | Chemical |
| Properties | |
| Formula | C12H15N5O3 . H2O |
| MW | 295.29 |
| CAS | 209216-23-9 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Solube in DMSO (10mg/ml), DMF (10mg/ml) or methanol. Sparingly soluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | YXPVEXCTPGULBZ-WQYNNSOESA-N |
| Smiles | O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1.O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Entecavir is an oral antiviral drug used in the treatment of hepatitis B (HBV) infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses. In vitro, the active intracellular form of entecavir, entecavir triphosphate, demonstrates a higher binding affinity for HBV DNA polymerase than the natural guanosine triphosphate substrate and effectively inhibits HBV DNA replication at 3 stages in the replication pathway: priming, reverse transcription and DNA-dependent DNA synthesis. Can be also used as a reference compound.
Product References
(1) S.F. Innaimo, et al.; Antimicrob. Agents Chemother. 41, 1444 (1997) | (2) M. Seifer, et al.; Antimicrob. Agents Chemother. 42, 3200 (1998) | (3) P. Honkoop & R.A. De Man; Expert. Opin. Investig. Drugs 12, 683 (2003) (Review) | (4) S.J. Matthews; Clin. Ther. 28, 184 (2006) (Review) | (5) K.A. Sims & A.M. Woodland; Pharmacotherapy 26, 1745 (2006) (Review) | (6) P.N. Cheng & T.T. Chang; Expert Rev. Anti. Infect. Ther. 6, 569 (2008) (Review)