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Chemodex
Eleutheroside A
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| Product Details | |
|---|---|
| Synonyms | Daucosterol; Daucosterin; β-Sitosterol β-D-glucoside; β-Sitosterol 3-O-glucoside; β-Sitosterol D-glucopyranoside; NSC 165962 |
| Product Type | Chemical |
| Properties | |
| Formula | C35H60O6 |
| MW | 576.85 |
| CAS | 474-58-8 |
| Source/Host Chemicals | Semisynthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white to pale beige powder. |
| Solubility | Soluble in DMSO (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | NPJICTMALKLTFW-OFUAXYCQSA-N |
| Smiles | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=CC3)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Eleutheroside A is a natural phytosterol glycoside that exerts multiple bioactivities, like anticancer, anti-inflammatory, immunomodulatory, antibacterial and antioxidant, via modulation of cell signaling, oxidative stress, and immune responses. It modulates immune, metabolic and tumor-associated pathways. Eleutheroside A can inhibit the PI3K/AKT1/mTOR signaling pathway in myeloid-derived suppressor cells (MDSCs), thereby reducing their glycolytic activity and immunosuppressive function in the tumor microenvironment of gastric cancer, which leads to enhanced CD4+/CD8+ T-cell infiltration and slowed tumor growth in vivo.
Product References
(1) J.-H. Lee, et al.; Vaccine 25, 3834 (2007) | (2) E.J. Cho, et al.; Hort. Environ. Biotechnol. 53, 561 (2012) | (3) C. Zhao, et al.; Life Sci. 137, 37 (2015) | (4) L.H. Jiang, et al.; J. Steroid Biochem. Mol. Biol. 152, 45 (2015) | (5) J. Zeng, et al.; Molecules 22, 862 (2017) | (6) H. Dehghan, et al.; Ind. Crops Prod. 117, 303 (2018) | (7) P. Gao, et al.; Biosci. Trends 13, 160 (2019) | (8) X. Jiang, et al.; Int. Immunopharmacol. 159, 114907 (2025)