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Chemodex
7-Ethoxycoumarin
39
CHF
CHF 39.00
In stock
CDX-E0252-M100100 mgCHF 39.00
CDX-E0252-M500500 mgCHF 116.00
| Product Details | |
|---|---|
| Synonyms | 7-Ethoxy-1-benzopyran-2-one; Ethylumbelliferone; 7-ethoxychromen-2-one |
| Product Type | Chemical |
| Properties | |
| Formula | C11H10O3 |
| MW | 190.2 |
| CAS | 31005-02-4 |
| RTECS | DJ3053100 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (GC) |
| Appearance | White to light brown powder. |
| Solubility | Soluble in ethanol (50 mg/ml) or DMSO (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | LIFAQMGORKPVDH-UHFFFAOYSA-N |
| Smiles | O=C1C=CC2=CC=C(OCC)C=C2O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
7-Ethoxycoumarin (7-EC) is a naturally occurring derivative of coumarin that is commonly found in numerous plant species. 7-Ethoxycoumarin is a substrate for cytochrome P450 (CYP450) has been used in the functional characterization of various CYPs. It undergoes O-deethylation by various CYP isoforms, including CYP1A1, -1A2, and -2B in mice and CYP2E1 in humans. Has been used in high-throughput screens in fluorometric p450 activity assays and is metabolized to the fluorescent metabolite 7-Hydroxycoumarin with λex=370nm; λem=450nm. This product can be used as analytical reference compound.
Product References
(1) A. Zitting; Anal. Biochem. 115, 177 (1981) | (2) H. Yamazaki, et al.; Biochem. Pharmacol. 51, 313 (1996) | (3) H. Yamazaki, et al.; J. Chromatogr. B Biomed. Sci. Appl. 721, 13 (1999) | (4) T. Shimada, et al.; Drug Metab. Dispos. 27, 1274 (1999) | (5) D.J. Waxman & T.K.H. Chang; Methods Mol. Biol. 320, 153 (2006) | (6) D.H. Kim, et al.; Drug Metab. Dispos. 36, 2166 (2008) | (7) T. Uno, et al.; Biopharm. Drug Dispos. 34, 87 (2013) | (8) W.Y.Feng, et al.; Drug Metab. Lett. 12, 33 (2018)