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Chemodex
5-Fluorocytosine
162
CHF
CHF 162.00
In stock
CDX-F0077-G0011 gCHF 162.00
CDX-F0077-G0055 gCHF 651.00
| Product Details | |
|---|---|
| Synonyms | 4-Amino-5-fluoro-2(1H)-pyrimidinone; Flucytosine; NSC 103805; Ancotil; 5-FC; Ancobon; Ro 2-9915 |
| Product Type | Chemical |
| Properties | |
| Formula | C4H4FN3O |
| MW | 129.09 |
| CAS | 2022-85-7 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (TLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XRECTZIEBJDKEO-UHFFFAOYSA-N |
| Smiles | NC1=NC(=O)NC=C1F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.
Product References
(1) R.J. Holt & R.L. Newman; J. Clin. Pathol. 26, 167 (1973) | (2) R.B. Diasio, et al.; Biochem. Pharmacol. 27, 703 (1978) | (3) D.G. Osterman, et al.; Biochemistry 27, 5204 (1988) | (4) T. Ichikawa, et al.; Cancer Gene Ther. 7, 74 (2000) | (5) C. Fuerer & R. Iggo; Gene Ther. 11, 142 (2004) | (6) K. Kurozumi, et al.; J. Neurooncol. 66, 117 (2004)
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