|Synonyms||4-Amino-5-fluoro-2(1H)-pyrimidinone; Flucytosine; NSC 103805; Ancotil; 5-FC; Ancobon; Ro 2-9915|
|Purity Chemicals||≥99% (TLC)|
|Appearance||White to off-white powder.|
|Solubility||Soluble in water.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.
(1) R.J. Holt & R.L. Newman; J. Clin. Pathol. 26, 167 (1973) | (2) R.B. Diasio, et al.; Biochem. Pharmacol. 27, 703 (1978) | (3) D.G. Osterman, et al.; Biochemistry 27, 5204 (1988) | (4) T. Ichikawa, et al.; Cancer Gene Ther. 7, 74 (2000) | (5) C. Fuerer & R. Iggo; Gene Ther. 11, 142 (2004) | (6) K. Kurozumi, et al.; J. Neurooncol. 66, 117 (2004)