5-Fluorocytosine

CHF 153.00
In stock
CDX-F0077-G0011 gCHF 153.00
CDX-F0077-G0055 gCHF 612.00
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Product Details
Synonyms 4-Amino-5-fluoro-2(1H)-pyrimidinone; Flucytosine; NSC 103805; Ancotil; 5-FC; Ancobon; Ro 2-9915
Product Type Chemical
Properties
Formula C4H4FN3O
MW 129.09
CAS 2022-85-7
Source/Host Chemicals Synthetic
Purity Chemicals ≥99% (TLC)
Appearance White to off-white powder.
Solubility Soluble in water.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key XRECTZIEBJDKEO-UHFFFAOYSA-N
Smiles NC1=NC(=O)NC=C1F
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.

Product References

(1) R.J. Holt & R.L. Newman; J. Clin. Pathol. 26, 167 (1973) | (2) R.B. Diasio, et al.; Biochem. Pharmacol. 27, 703 (1978) | (3) D.G. Osterman, et al.; Biochemistry 27, 5204 (1988) | (4) T. Ichikawa, et al.; Cancer Gene Ther. 7, 74 (2000) | (5) C. Fuerer & R. Iggo; Gene Ther. 11, 142 (2004) | (6) K. Kurozumi, et al.; J. Neurooncol. 66, 117 (2004)

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