Flumequine

CHF 89.00
In stock
CDX-F0079-G0055 gCHF 89.00
CDX-F0079-G02525 gCHF 357.00
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Product Details
Synonyms 9-Fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid
Product Type Chemical
Properties
Formula C14H12FNO3
MW 261.3
CAS 42835-25-6
RTECS DK1672000
Source/Host Chemicals Synthetic.
Purity Chemicals ≥97% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in toluene.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key DPSPPJIUMHPXMA-UHFFFAOYSA-N
Smiles CC1CCC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Flumequine is a fluoroquinolone synthetic chemotherapeutic antibiotic used to treat bacterial infections. Targets primarily gram negative bacteria, especially those which cause enteric infections in animals. It is used to study processes that affect mammalian chromosome and DNA unwinding at the level of gyrase/topoisomerases. It inhibits topoisomerases, which are needed for the transcription and replication of bacterial DNA. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling and resealing. Therefore, DNA replication and transcription is inhibited. It was also used to study hepatocarcinogenicity and DNA damage in mice and the mechanisms of quinolone resistance.

Product References

(1) G. Stilwell, et al.; Antimicrob. Agents Chemother. 7, 483 (1975) | (2) S.R. Rohlfing, et al.; J. Antimicrob. Chemother. 3, 615 (1977) | (3) M. Yoshida, et al.; Cancer Lett. 141, 99 (1999) | (4) A. Ruiz-Garcia, et al.; Eur. J. Pharm. Biopharm. 48, 253 (1999) | (5) Y. Kashida, et al.; Toxicol. Sci. 69, 317 (2002) | (6) Y. Kuroiwa, et al.; Arch. Toxicol. 81, 63 (2007)

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