Fluoxetine hydrochloride

CHF 27.00
In stock
CDX-F0141-M01010 mgCHF 27.00
CDX-F0141-M05050 mgCHF 68.00
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Product Details
Synonyms (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride; LY-110,140 hydrochloride; Prozac
Product Type Chemical

C17H18F3NO . HCl

MW 345.79
CAS 56296-78-7
RTECS UI4050000
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in water (2mg/ml), DMSO (10mg/ml), DMF (10mg/ml) or ethanol (5mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Smiles C[NH2+]CCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[Cl-]
Shipping and Handling
Shipping AMBIENT
Short Term Storage +20°C
Long Term Storage +20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at RT.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Fluoxetine is a cell-permeable selective serotonin reuptake inhibitor (SSRI), with preference for the serotonin transporter (Kd=0.81nM) over the norepinephrine transporter (Kd=240nM) and the dopamine transporter (Kd=3600nM). This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses. It functions as an antidepressant. Fluoxetine binds also to the human 5-HT transporter and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. It has been shown to induce differentiation of neuronal precursors, enhancing neuronal characteristics. In addition, it was reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC) and to regulate the phosphorylation of DARPP-32 and AMPA receptors.

Product References

(1) P. Benfield, et al.; Drugs 32, 481 (1986) | (2) D.T. Wong, et al.; Life Sci. 57, 411 (1995) | (3) M. Tatsumi, et al.; Eur. J. Pharmacol 340, 249 (1997) | (4) S.G. Beck, et al.; J. Pharmacol. Exp. Ther. 281, 115 (1997) | (5) M.J. Owens, et al.; J. Pharmacol. Exp. Ther. 283, 1305 (1997) | (6) V.A. Edgar, et al.; Eur. J. Pharmacol. 372, 65 (1999) | (7) P. Bartholoma, et al.; Biochem. Pharmacol. 63, 1507 (2002) | (8) J.T. Bian, et al.; Eur. J. Pharmacol. 453, 159 (2002) | (9) A. Zhang, et al.; J. Med. Chem. 45, 1930 (2002) | (10) P. Svenningsson, et al.; PNAS 99, 3182 (2002) | (11) L. Perez-Caballero, et al.; Expert Opin. Drug Discov. 9, 567 (2014)

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