|Synonyms||Vitamin Bc; Vitamin Be; Vitamin B9; NSC 3073; PteGlu; Pteroyl-L-glutamic acid; Pteroylglutamic acid; Vitamin M; N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; Pteroylmonoglutamic acid|
|Purity Chemicals||≥95% (HPLC)|
|Appearance||Yellow to orange crystalline powder.|
|Solubility||Soluble in 1M NaOH (50 mg/ml), diluted acids or allkaline solutions. Slightly soluble in water (1.6mg/ml) or methanol.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+20°C|
|Long Term Storage||+4°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
Folic acid, also known as folate, is a B vitamin is an essential nutritional component of the human diet. It is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis, and for preventing changes to DNA, and consequently cancer. It is especially important during periods of frequent cell division and growth, such as infancy and pregnancy. Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis. Folic acid deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. Both adults and children need folate to make normal red and white blood cells and prevent anemia. Deficiency of folic acid in pregnant women has been implicated in neural tube defects (NTD).
(1) B. Kamen; Semin. Oncol. 24, S18-30 (1997) | (2) Y.I. Kim; Nutr. Rev. 57, 314 (1999) | (3) S.W. Choi & J.B. Mason; J. Nutr. 130, 129 (2000) | (4) P. Mastroiacovo & E. Leoncini; Biofactors 37, 272 (2011) | (5) S.Y. Taylor, et al.; Eur. J. Pharmacol. 714, 193 (2013) | (6) N. Laurieri, et al.; PLoS One 9, e96370 (2014) | (7) S.Y. Hwang, et al.; Int. J. Mol. Med. 36, 1073 (2015) | (8) H.N. Moussa, et al.; Future Sci. OA. 2, 2 (2016)