Guanidine thiocyanate

CHF 68.00
In stock
CDX-G0058-G100100 gCHF 68.00
CDX-G0058-G500500 gCHF 198.00
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Product Details
Synonyms Guanidinium rhodanide; GTC; Guanidinium isothiocyanate; Guanidinium thiocyanate
Product Type Chemical
Formula CH5N3 . CHNS
MW 59.07 . 59.09
CAS 593-84-0
RTECS XL1225000
Purity Chemicals ≥99% (Titration)
Appearance White to off-white powder.
Solubility Soluble in water (10M) or DMSO.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Smiles NC(N)=N.SC#N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +20°C
Long Term Storage +20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at RT.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Guanidine thiocyanate is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms and is commonly used in the guanidinium thiocyanate-phenol-chloroform extraction method. As one of the strongest protein denaturants, it inactivates nucleases more than twice as fast as Guanidine hydrochloride. It is useful for denaturation and refolding of proteins. At high molarity solutions, Guanidine thiocyanate irreversibly inactivates RNase. Guanidine thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.

Product References

(1) S. Lapanje; Biochim. Biophys. Acta 243, 349 (1971) | (2) S. Lapanje; Biochim. Biophys. Acta 243, 357 (1971) | (3) W.C. Johnson, et al.; Appl. Microbiol. 29, 405 (1975) | (4) R. McGookin; Methods Mol. Biol. 2, 113 (1985) | (5) P. Chomczynski, et al.; Anal. Biochem. 162, 156 (1987) | (6) T. Nakano & A.L. Fink; J. Biol. Chem. 265, 12356 (1990) | (7) S. Emadi & M. Behzadi; BBRC 450, 1339 (2014)

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