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Chemodex
Genistein
81
CHF
CHF 81.00
In stock
CDX-G0210-M02525 mgCHF 81.00
CDX-G0210-M100100 mgCHF 244.00
| Product Details | |
|---|---|
| Synonyms | CI-75610; NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H10O5 |
| MW | 270.24 |
| CAS | 446-72-0 |
| RTECS | NR2392000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white to yellow powder. |
| Solubility | Soluble in DMSO (30mg/ml). Slightly soluble in ethanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Smiles | OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Genistein is an isoflavonoid phytoestrogen that has been found in soybeans and has kinase inhibitory, anticancer, pro-cancer and hepatoprotective properties. It is a cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Genistein inhibits proliferation and induces cell cycle arrest and apoptosis in a variety of cancer cells. It is antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. On a molecular level it also inhibits mammalian DNA topoisomerase II and DNA methyltransferase, and binds to estrogen receptor β. Genistein has also antidiabetic, anti-inflammatory, antimicrobial and antioxidant properties. It is an α-glucosidase inhibitor, PPAR activator, GLUT4-mediated glucose uptake inhibitor, MALT1 inhibitor and acts as an agonist at the GPR30 receptor.
Product References
(1) T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) | (2) J. Markovits, et al.; Cancer Res. 49, 5111 (1989) | (3) G. Peterson & S. Barnes; BBRC 179, 661 (1991) | (4) DS. Lee & SH. Lee; FEBS Lett. 501, 84 (2001) | (5) P.K. Kar, et al.; Parasitol. Int. 51, 249 (2002) | (6) O. Mezei, et al.; J. Nutr. 133, 1238 (2003) | (7) Z.C. Dang, et al.; J. Biol. Chem. 278, 962 (2003) | (8) M. Bazuine, et al.; BBRC 326, 511 (2005) | (9) Y.H. Ju, et al.; Carcinogenesis 27, 1292 (2006) | (10) RM. Han, et al.; J. Agric. Food Chem. 57, 3780 (2009) | (11) Z.C. Dang; Obes. Rev. 10, 342 (2009) (Review) | (12) L.J. Luo, et al.; Arch. Biochem. Biophys. 522, 9 (2012) | (13) L. Fontan, et al.; Cancer Cell 22, 812 (2012) | (14) V. Singh, et al.; Curr. Cancer Drug Targets 13, 379 (2013) | (15) SY. Wang, et al.; Phytother. Res. 28, 1071 (2014) | (16) C. Spagnuolo, et al.; Adv. Nutr. 6, 408 (2015)