Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Genistein
As low as
81
CHF
CHF 81.00
In stock
Only %1 left
CDX-G0210-M02525 mgCHF 81.00
CDX-G0210-M100100 mgCHF 244.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | CI-75610; NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H10O5 |
| MW | 270.24 |
| CAS | 446-72-0 |
| RTECS | NR2392000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white to yellow powder. |
| Solubility | Soluble in DMSO (30mg/ml). Slightly soluble in ethanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Smiles | OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Genistein is an isoflavonoid phytoestrogen that has been found in soybeans and has kinase inhibitory, anticancer, pro-cancer and hepatoprotective properties. It is a cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Genistein inhibits proliferation and induces cell cycle arrest and apoptosis in a variety of cancer cells. It is antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. On a molecular level it also inhibits mammalian DNA topoisomerase II and DNA methyltransferase, and binds to estrogen receptor β. Genistein has also antidiabetic, anti-inflammatory, antimicrobial and antioxidant properties. It is an α-glucosidase inhibitor, PPAR activator, GLUT4-mediated glucose uptake inhibitor, MALT1 inhibitor and acts as an agonist at the GPR30 receptor.
Product-specific References
(1) T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) | (2) J. Markovits, et al.; Cancer Res. 49, 5111 (1989) | (3) G. Peterson & S. Barnes; BBRC 179, 661 (1991) | (4) DS. Lee & SH. Lee; FEBS Lett. 501, 84 (2001) | (5) P.K. Kar, et al.; Parasitol. Int. 51, 249 (2002) | (6) O. Mezei, et al.; J. Nutr. 133, 1238 (2003) | (7) Z.C. Dang, et al.; J. Biol. Chem. 278, 962 (2003) | (8) M. Bazuine, et al.; BBRC 326, 511 (2005) | (9) Y.H. Ju, et al.; Carcinogenesis 27, 1292 (2006) | (10) RM. Han, et al.; J. Agric. Food Chem. 57, 3780 (2009) | (11) Z.C. Dang; Obes. Rev. 10, 342 (2009) (Review) | (12) L.J. Luo, et al.; Arch. Biochem. Biophys. 522, 9 (2012) | (13) L. Fontan, et al.; Cancer Cell 22, 812 (2012) | (14) V. Singh, et al.; Curr. Cancer Drug Targets 13, 379 (2013) | (15) SY. Wang, et al.; Phytother. Res. 28, 1071 (2014) | (16) C. Spagnuolo, et al.; Adv. Nutr. 6, 408 (2015)