Glycyrrhizic acid ammonium salt

Specifications / Handling

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Product Details
Synonyms	Glycyrrhizin; 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid ammonium salt; Monoammonium glycyrrhizinate; NSC 2800; NSC 35348
Product Type	Chemical
Properties
Formula	C₄₂H₆₂O₁₆ . NH₃
MW	839.96
CAS	53956-04-0
RTECS	LZ6500000
Source/Host Chemicals	Plant
Purity Chemicals	≥98% (Titr.)
Appearance	White powder.
Solubility	Soluble in DMSO (10mg/ml). Slightly soluble in water (1mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	ILRKKHJEINIICQ-IERXZFCASA-N
Smiles	O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](C(O)=O)O[C@@H]2O[C@H]3C(C)(C)[C@@](CC[C@]([C@@](CC[C@]4(C)[C@@]5([H])C[C@@](C)(C(O)=O)CC4)(C)C5=C6)(C)[C@]7([H])C6=O)([H])[C@]7(C)CC3)O1.N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Glycyrrhizic acid is a natural triterpenoid saponin. It is an agonist of the human sweet taste receptor and is used as a flavorant. Glycyrrhizic acid has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and antiviral actions. Glycyrrhizic acid has been shown to be a 11-β-hydroxysteroid dehydrogenase inhibitor, a functional inhibitor of HMGB1 and a highly selective and competitive inhibitor of kynurenine aminotransferase 2 (KAT2). It can enhance GLP-1 secretion through TGR5 activation and has an anti-inflammatory effect by attenuating the generation of excessive NO, PGE(2), and ROS and by suppressing the expression of pro-inflammatory genes through the inhibition of NF-κ and PI3K activity. It has anti-angiogenic and apoptosis inducing properties. In addition, due to its amphiphilic nature glycyrrhizic acid is able to form self-associates in aqueous and non-aqueous media, as well as water soluble complexes with a wide range of lipophilic drugs. It has been identified as promising carrier material for anticancer therapy, due to its anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms.

Product References

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