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Chemodex
Ginkgolide B
41
CHF
CHF 41.00
In stock
CDX-G0218-M01010 mgCHF 41.00
CDX-G0218-M05050 mgCHF 143.00
| Product Details | |
|---|---|
| Synonyms | BN-52021 |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24O10 |
| MW | 424.4 |
| CAS | 15291-77-7 |
| RTECS | KC9949000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (30mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | SQOJOAFXDQDRGF-MMQTXUMRSA-N |
| Smiles | O=C1[C@@H](C)[C@]([C@](O1)([H])[C@@H]2O)(O)[C@]([C@]32[C@@]4([H])C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation. Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation and platelet aggregation. These cellular effects are mediated through its specific G-protein coupled receptor, PAFR. Ginkgolide B has been shown to have anticancer properties by inducing apoptosis and blocking the cell cycle. Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant and neuroprotective effects.
Product References
(1) E. Foldes-Filep, et al.; BBRC 148, 1412 (1987) | (2) K. Funkunaga, et al.; J. Biol. Chem. 276, 43025 (2001) | (3) K.M. Maclennan, et al.; Prog. Neurobiol. 67, 235 (2002) | (4) E.L. Kondratskaya, et al.; Brain Res. Bull. 63, 309 (2004) | (5) X. Shi-hai & F. Dian-chun; Chin. Med. J. 120, 922 (2007) | (6) H.J. Cho & K.S. Nam; J. Biochem. Mol. Biol. 40, 678 (2007) | (7) M. Aponte, et al.; Cancer Res. 68, 5839 (2008) | (8) Y.D. Hsuuw, et al.; Ann. N Y Acad. Sci. 1171, 501 (2009) | (9) S. Zhang, et al.; J. Cardiovasc. Pharmacol. 57, 721 (2011) | (10) C. Zhang, et al.; Toxicology 287, 124 (2011) | (11) X. Chu, et al.; Molecules 16, 7634 (2011) | (12) W. Jiang, et al.; Integr. Cancer Ther. 13, NP10-7 (2012) | (13) J.H. Gu, et al.; Eur. J. Pharm. Sci. 47, 652 (2012)