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Chemodex
Ginkgolide A
122
CHF
CHF 122.00
In stock
CDX-G0221-M02525 mgCHF 122.00
| Product Details | |
|---|---|
| Synonyms | BN-52020 |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24O9 |
| MW | 408.4 |
| CAS | 15291-75-5 |
| RTECS | KC9943000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (3mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | FPUXKXIZEIDQKW-VKMVSBOZSA-N |
| Smiles | O=C1[C@@H](C)[C@]([C@](O1)([H])C2)(O)[C@]([C@]32[C@H]4C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-κ activity by NF-κ-specific suppressor IκBα. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.
Product References
(1) H.W. Zhao & X.Y. Li; Int. Immunopharmacol. 2, 1551 (2002) | (2) H. Kuribara, et al.; J. Nat. Prod. 66, 1333 (2003) | (3) E. Koch; Phytomedicine 12, 10 (2005) | (4) B. Ye, et al.; Cancer Lett. 251, 43 (2007) | (5) Q. Zhao, et al.; Int. Immunopharmacol. 25, 242 (2015) | (6) N. Ye, et al.; Biomol. Ther. 24, 40 (2016) | (7) J. Zhaocheng, et al.; Pharmazie 71, 588 (2016) | (8) H.S. Jeong, et al.; Biomed. Pharmacother. 88, 625 (2017) | (9) Y. Li, et al.; Int. J. Mol. Sci. 18, E794 (2017) | (10) L.C. Kuo, et al.; J. Agric. Food Chem. 67, 81 (2019) | (11) S. Mohandas & B. Vairappan; Chem. Biol. Interact. 315, 108891 (2019) | (12) W. You, et al.; Pharmazie 74, 698 (2019)