4-Hydroxyphenylpyruvic acid

CHF 51.00
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CDX-H0013-G0011 gCHF 51.00
CDX-H0013-G0055 gCHF 204.00
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Product Details
Synonyms 3-(4-Hydroxyphenyl)-2-oxopropanoic acid; 4-HPPA; p-Hydroxyphenylpyruvic acid
Product Type Chemical
Properties
Formula C9H8O4
MW 180.16
CAS 156-39-8
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance Light yellow crystalline.
Solubility Soluble in water, ethanol (50 mg/ml), ether or methanol.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key KKADPXVIOXHVKN-UHFFFAOYSA-N
Smiles OC(=O)C(=O)CC1=CC=C(O)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.

Product References

(1) C.H. Doy, et al.; Nature 186, 529 (1960) | (2) W. Loffelhardt & H. Kindl; FEBS Lett 104, 332 (1979) | (3) K. Tomoeda, et al.; Mol. Genet. Metab. 71, 506 (2000) | (4) E. van Dyk & P. Pretorius; BBRC 338, 815 (2005)

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