|Synonyms||3-(4-Hydroxyphenyl)-2-oxopropanoic acid; 4-HPPA; p-Hydroxyphenylpyruvic acid|
|Purity Chemicals||≥98% (HPLC)|
|Appearance||Light brown crystalline.|
|Solubility||Soluble in water, ethanol (50 mg/ml), ether or methanol.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
(1) C.H. Doy, et al.; Nature 186, 529 (1960) | (2) W. Loffelhardt & H. Kindl; FEBS Lett 104, 332 (1979) | (3) K. Tomoeda, et al.; Mol. Genet. Metab. 71, 506 (2000) | (4) E. van Dyk & P. Pretorius; BBRC 338, 815 (2005)