5-Hydroxydiclofenac

Specifications / Handling

More Information
Product Details
Synonyms	2-[(2,6-Dichlorophenyl)amino]-5-hydroxybenzeneacetic acid; 5-OH-DFN; 5-OH DCF; BRN4199419
Product Type	Chemical
Properties
Formula	C₁₄H₁₁Cl₂NO₃
MW	312.2
CAS	69002-84-2
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥97% (HPLC)
Appearance	Light grey powder.
Solubility	Soluble in DMSO or acetone.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	VNQURRWYKFZKJZ-UHFFFAOYSA-N
Smiles	OC1=CC=C(NC2=C(Cl)C=CC=C2Cl)C(CC(O)=O)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound that functions via inhibiton of cyclooxygenase (COX). Diclofenac undergoes biotransformation not only by glucuronidation, but also by cytochrome P450–mediated oxidation to produce 4'-OH-DFN and 5-OH-DFN, which undergo subsequent oxidation to form highly electrophilic benzoquinone imine intermediates. Compound can be used as analytical reference material.

Product References

(1) J.R. Kenny, et al.; J. Med. Chem. 47, 2816 (2004) | (2) D.J. Naisbitt, et al.; Toxicol. Lett. 168, 45 (2007) | (3) D. Stülten, et al.; Sci. Total Environ. 405, 310 (2008) | (4) D.J. Waldon, et al.; Chem. Res. Toxicol. 23, 1947 (2010) | (5) J. Surendradoss, et al.; Drug Metab. Disp. 42, 1834 (2014)

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