5-Hydroxydiclofenac

CHF 115.00
In stock
CDX-H0053-M0011 mgCHF 115.00
CDX-H0053-M0055 mgCHF 459.00
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Product Details
Synonyms 2-[(2,6-Dichlorophenyl)amino]-5-hydroxybenzeneacetic acid; 5-OH-DFN; 5-OH DCF; BRN4199419
Product Type Chemical
Properties
Formula C14H11Cl2NO3
MW 312.2
CAS 69002-84-2
Source/Host Chemicals Synthetic.
Purity Chemicals ≥97% (HPLC)
Appearance Light grey powder.
Solubility Soluble in DMSO or acetone.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key VNQURRWYKFZKJZ-UHFFFAOYSA-N
Smiles OC1=CC=C(NC2=C(Cl)C=CC=C2Cl)C(CC(O)=O)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound that functions via inhibiton of cyclooxygenase (COX). Diclofenac undergoes biotransformation not only by glucuronidation, but also by cytochrome P450–mediated oxidation to produce 4'-OH-DFN and 5-OH-DFN, which undergo subsequent oxidation to form highly electrophilic benzoquinone imine intermediates. Compound can be used as analytical reference material.

Product References

(1) J.R. Kenny, et al.; J. Med. Chem. 47, 2816 (2004) | (2) D.J. Naisbitt, et al.; Toxicol. Lett. 168, 45 (2007) | (3) D. Stülten, et al.; Sci. Total Environ. 405, 310 (2008) | (4) D.J. Waldon, et al.; Chem. Res. Toxicol. 23, 1947 (2010) | (5) J. Surendradoss, et al.; Drug Metab. Disp. 42, 1834 (2014)

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