5-Hydroxy-L-tryptophan

Specifications / Handling

More Information
Product Details
Synonyms	Oxitriptan; 5-HTP; L-2-Amino-3-(5-hydroxyindolyl)propionic acid; L-5-HTTP; L-5-Hydroxytryptophan
Product Type	Chemical
Properties
Formula	C₁₁H₁₂N₂O₃
MW	220.22
CAS	4350-09-8
RTECS	YN7110000
Source/Host Chemicals	Isolated from plant source.
Purity Chemicals	≥99% (HPLC)
Appearance	Off-white powder.
Solubility	Soluble in water, chloroform or DMSO.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	LDCYZAJDBXYCGN-VIFPVBQESA-N
Smiles	OC1=CC=C(NC=C2C[C@H](N)C(O)=O)C2=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

5-hydroxy-L-Tryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. It is used as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. It is also used as L-aromatic amino acid decarboxylase substrate. When injected systemically in animals, 5-HTP is converted to serotonin and has both peripheral and central nervous system effects. 5-HTP can also be synthesized by gut microbiota and acts as an activator of the aryl hydrocarbon receptor.

Product References

(1) A. Carlsson, et al.; Nature 180, 1200 (1957) | (2) A. Boiardi, et al.; J. Neurol. 225, 41 (1981) | (3) T.C. Birdsall; Altern. Med. Rev. 3, 271 (1998)| (4) A. Martinez, et al.; Curr. Med. Chem. 8, 1077 (2001) | (5) E.H. Turner, et al.; Pharmacol. Ther. 109, 325 (2006) | (6) C.L. Schmid & L.M. Bohn; J. Neurosci. 30, 13513 (2010) | (7) G.V. Sridharan, et al.; Nat. Commun. 5, 5492 (2014) | (8) R. Haberzettl, et al.; Behav. Brain Res. 277, 204 (2015) | (9) J.-A. Mora-Villalobos & A.-P. Zeng; J. Biol. Eng. 12, 3 (2018)

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