Heptakis(2,6-di-O-methyl)-β-cyclodextrin

DIMEB (Heptakis(2,6-di-O-methyl)-β-cyclodextrin) is a complexing agent, a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is a hydrophilic derivative of cyclodextrin that possesses the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E and K, etc. It can be utilized to increase the dissolution and bioavailability of poorly water-soluble pharmaceutical preparations, as well as their stability. This compound is particularly valuable in the study of molecular encapsulation, where it is used to investigate the inclusion of various hydrophobic molecules within its cavity, thereby improving their solubility and stability. In analytical chemistry, DIMEB serves as a chiral stationary phase in chromatography, aiding in the separation of enantiomers. DIMEB is used in the investigation of drug delivery systems and as cell penetration enhancer. It can help drugs penetrate cell membranes, which is important for delivering drugs inside cells. It has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides and heavy metals.