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Chemodex
Hederacoside C
95
CHF
CHF 95.00
In stock
CDX-H0299-M05050 mgCHF 95.00
| Product Details | |
|---|---|
| Synonyms | Hederasaponin C; Kalopanaxsaponin B |
| Product Type | Chemical |
| Properties | |
| Formula |
C59H96O26 |
| MW | 1221.38 |
| CAS | 14216-03-6 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (5mg/ml), DMF (15mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | RYHDIBJJJRNDSX-MCGLQMIESA-N |
| Smiles | O=C(O[C@H](O[C@@H]1CO[C@H](O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]2O[C@@](O[C@H]3C)([H])[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]1O)[C@@]4(CC5)CC[C@]6(C)C([C@]4([H])CC5(C)C)=CC[C@@]7([H])[C@@]6(C)CC[C@]8([H])[C@]7(C)CC[C@H](O[C@@](OC[C@@H]9O)([H])[C@]([C@H]9O)([H])O[C@H](O[C@H]%10C)[C@H](O)[C@H](O)[C@H]%10O)[C@@]8(C)CO |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-α, IL-1β, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-κ (p65 and IκBα) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and IκBα.
Product References
(1) A. Gepdiremen, et al.; Phytomedicine 12, 440 (2005) | (2) E.H. Joh, et al.; Cell Immunol. 279, 103 (2012) | (3) E.H. Joh, et al.; Phytother. Res. 26, 546 (2012) | (4) M. Akhtar, et al.; Inflammation (Epub ahead of print) (2019) | (5) M. Akhtar, et al.; Microb. Pathog. 137, 103767 (2019)