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Chemodex
L-Homoserine lactone hydrobromide
129
CHF
CHF 129.00
In stock
CDX-H0310-G0055 gCHF 129.00
| Product Details | |
|---|---|
| Synonyms | (S)-(-)-α-Amino-γ-butyrolactone hydrobromide; L-Homoserine lactone HBr |
| Product Type | Chemical |
| Properties | |
| Formula |
C4H7NO2 . HBr |
| MW | 182.02 |
| CAS | 15295-77-9 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to beige powder. |
| Solubility | Soluble in water (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | MKLNTBLOABOJFZ-DFWYDOINSA-N |
| Smiles | O=C1[C@@H]([NH3+])CCO1.[Br-] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
L-Homoserine lactone hydrobromide is used as a building block. It can be used to prepare β-ketoamide N-acylated-L-homoserine lactones (AHLs) as quorum sensing molecules, p-coumaroyl-HSL (homoserine lactone), calpain and lipid peroxidation inhibitors and pseudopeptide inhibitors for Ras farnesyl-protein transferase, as well as selenomethionine.
Product References
(1) T. Koch & O. Buchardt; Synthesis 1065-1067 (1993) | (2) S.L Graham, et al.; J. Med. Chem. 37,725 (1994) | (3) S. Auvin, et al.; Bioorg. Med. Chem. Lett. 14, 3825 (2004) | (4) A.L. Schaefer, et al.; Nature 454, 595 (2008) | (5) J.T. Hodgkinson, et al., Tetrahedr. Lett. 52, 3291 (2011) | (6) D. Jakubczyk, et. al.; Eur. J. Org. Chem. 592, 2014 (2014) | (7) N. Nandakumar, et al.; Bioorg. Med. Chem. Lett. 27, 2967 (2017) | (8) G. Wu, et al.; Chem. Commun. 55, 7860 (2019) | (9) L. Ziesche, et al.; Mar. Drugs 17, 20 (2019)