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Chemodex
(2-Hydroxypropyl)-β-cyclodextrin
As low as
103
CHF
CHF 103.00
In stock
Only %1 left
CDX-H0352-G02525 gCHF 103.00
CDX-H0352-G100100 gCHF 226.00
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| Product Details | |
|---|---|
| Synonyms | HBC; HP-β-CD; 2-Hydroxypropyl ethers β-cyclodextrin; (2-Hydroxypropyl)-beta-cyclodextrin |
| Product Type | Chemical |
| Properties | |
| Formula | C63H112O42 |
| MW | 1541.54 |
| CAS | 128446-35-5 |
| RTECS | GU2293332 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (100mg/ml) or DMSO (10mg/ml). |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ODLHGICHYURWBS-RYJYQAAZSA-N |
| Smiles | O[C@@H]([C@@H]1O)[C@H]2C(O[C@@H]1O[C@@H]([C@H]3O)C(O[C@@H]([C@H]3O)O[C@H]4[C@@H]([C@@H]([C@H](OC4COCC(O)C)O[C@@H]([C@@H]5O)C(O[C@@H]([C@H]5O)O[C@@H]6C(C([C@@H](O[C@@H]6COCC(O)C)O[C@@H]7C(C([C@@H](O[C@@H]7COCC(O)C)O[C@@H]([C@H]8O)C(O[C@@H]([C@H]8O)O2)COCC(O)C)O)O)O)O)COCC(O)C)O)O)COCC(O)C)COCC(O)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility. HP-β-CD is a mixture containing HP-β-CD with variable hydroxypropyl group substitutions and is a widely used drug delivery vehicle to improve the stability and bioavailability of bioactive compounds. HP-β-CD is also a cholesterol modifier and has shown anticancer activity.
Product References
(1) M.E. Brewster, et al.; Pharm. Res. 8, 792 (1991) | (2) T.F. Meert, et al.; Eur. J. Anaesthesiol. 9, 399 (1992) | (3) A.E. Christian, et al.; J. Lipid Res. 38, 2264 (1997) | (4) J. Peeters, et al.; J. Pharm. Sci. 91, 1414 (2002) | (5) V.M. Rao, et al.; Int. J. Pharm. 319, 98 (2006) | (6) C.W. Yong, et al.; Pharm. Res. 25, 1092 (2008) | (7) B.D. Shewale, et al.; Indian J. Pharm. Sci. 70, 255 (2008) | (8) M.E. Brewster, et al.; Eur. J. Pharm. Sci. 34, 94 (2008) | (9) T. Loftsson, et al.; Acta. Ophthalmol. 90, 603 (2012) | (10) A.R. Katageri & M.A. Sheikh; Int. Res. J. Pharm. 3, 52 (2012) | (11) M. Yokoo, et al.; PLoS One 10, e0141946 (2015) | (12) A.R.S. Couto, et al.; Materials 11, 1971 (2018)