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Chemodex
Ivabradine hydrochloride
CHF 0.00
Out of stock
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| Product Details | |
|---|---|
| Synonyms | 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride; Corlentor; Corlanor; Procoralan |
| Product Type | Chemical |
| Properties | |
| Formula | C27H36N2O5 . HCl |
| MW | 505.05 |
| CAS | 148849-67-6 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to beige powder. |
| Solubility | Soluble in water (10mg/ml), DMSO (20mg/ml) or DMF (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| Smiles | COC(C=C1C(C[C@@H]1CN(CCCN2CCC3=CC(OC)=C(OC)C=C3CC2=O)C)=C4)=C4OC.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Ivabradine hydrochloride is an open channel blocker of neuronal I(h) and related cardiac I(f) channels, which are comprised of subunits of the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels. In vivo, ivabradine has antianginal activity, it reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction. Formulations containing ivabradine have been used in the treatment of heart failure and angina.
Product References
(1) C. Thollon, et al.; Br. J. Pharmacol. 112, 37 (1994) | (2) P. Bois, et al.; Br. J. Pharmacol. 118, 1051 (1996) | (3) I. Ragueneau, et al.; Clin. Pharmacol. Ther. 64, 192 (1998) | (4) J.S. Borer, et al.; Circulation 107, 817 (2003) | (5) M. Melchiorre, et al.; J. Med. Chem. 53, 6773 (2010) | (6) U. Mackiewicz, et al.; J. Cell Physiol. 229, 813 (2014) | (7) M. Novella Romanelli, et al.; Curr. Top. Med. Chem. 16, 1764 (2016)