Chemodex

Ivabradine hydrochloride

Name: Ivabradine hydrochloride
Brand: Chemodex
SKU: CDX-I0177
Price: 77.00 CHF
Availability: InStock

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CDX-I0177-M01010 mgCHF 77.00

CDX-I0177-M05050 mgCHF 284.00

Specifications / Handling

More Information
Product Details
Synonyms	3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride; Corlentor; Corlanor; Procoralan
Product Type	Chemical
Properties
Formula	C₂₇H₃₆N₂O₅ . HCl
MW	505.05
CAS	148849-67-6
Source/Host Chemicals	Synthetic
Purity Chemicals	≥98% (HPLC)
Appearance	White to beige powder.
Solubility	Soluble in water (10mg/ml), DMSO (20mg/ml) or DMF (20mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	HLUKNZUABFFNQS-ZMBIFBSDSA-N
Smiles	COC(C=C1C(C[C@@H]1CN(CCCN2CCC3=CC(OC)=C(OC)C=C3CC2=O)C)=C4)=C4OC.Cl
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Ivabradine hydrochloride is an open channel blocker of neuronal I(h) and related cardiac I(f) channels, which are comprised of subunits of the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels. In vivo, ivabradine has antianginal activity, it reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction. Formulations containing ivabradine have been used in the treatment of heart failure and angina.

Product-specific References

(1) C. Thollon, et al.; Br. J. Pharmacol. 112, 37 (1994) | (2) P. Bois, et al.; Br. J. Pharmacol. 118, 1051 (1996) | (3) I. Ragueneau, et al.; Clin. Pharmacol. Ther. 64, 192 (1998) | (4) J.S. Borer, et al.; Circulation 107, 817 (2003) | (5) M. Melchiorre, et al.; J. Med. Chem. 53, 6773 (2010) | (6) U. Mackiewicz, et al.; J. Cell Physiol. 229, 813 (2014) | (7) M. Novella Romanelli, et al.; Curr. Top. Med. Chem. 16, 1764 (2016)

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