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Chemodex
Irbesartan
As low as
108
CHF
CHF 108.00
In stock
Only %1 left
CDX-I0204-M05050 mgCHF 108.00
CDX-I0204-M250250 mgCHF 434.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | 2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one; Avapro; BMS-186295; SR-47436 |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H28N6O |
| MW | 428.5 |
| CAS | 138402-11-6 |
| RTECS | HM2950270 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | YOSHYTLCDANDAN-UHFFFAOYSA-N |
| Smiles | O=C1C2(CCCC2)N=C(CCCC)N1CC(C=C3)=CC=C3C4=CC=CC=C4C5=NN=NN5 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Irbesartan is an orally available angiotensin II type 1 (AT1) receptor antagonist (IC50 = 1.3 nM) with antihypertensive activity. It binds to AT1 receptor with >5000 times higher affinity compared to AT2 receptor. Irbesartan also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and exhibits metabolic, anti-inflammatory and antioxidative properties. Irbesartan inhibits the receptor for advanced glycation end-products (RAGE)/high mobility group box 1 (HMGB1) axis and maybe useful in prevention and treatment of various diseases. Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.
Product-specific References
(1) L. Ruilope; J. Hypertens. Suppl. 15, S15 (1997) (Review) | (2) M. Burnier; Circulation 103, 904 (2001) | (3) A.H. Gradman; J. Human Hypert. 16, S9 (2002) | (4) K. Kikuchi, et al.; Int. J. Mol. Sci. 14, 18899 (2013) (Review) | (5) Z.Z. Zhang, et al.; J. Transl. Med. 11, 229 (2013) | (6) I. Taguchi, et al.; Hypertens. Res. 36, 608 (2013) | (7) I.T. Abdel-Raheem, et al.; Fundam. Clin. Pharmacol. 29, 286 (2015) | (8) J. Zhong, et al.; Int. Immunopharmacol. 42, 176 (2017) | (9) I.A. Darwish, et al.; Prof. Drug Subst. Excip. Rel. Meth. 46, 185 (2021) (Review)