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Chemodex
Linezolid
162
CHF
CHF 162.00
In stock
CDX-L0031-M02525 mgCHF 162.00
| Product Details | |
|---|---|
| Synonyms | N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide; PNU-100766; U-100766 |
| Product Type | Chemical |
| Properties | |
| Formula | C16H20FN3O4 |
| MW | 337.35 |
| CAS | 165800-03-3 |
| RTECS | AC2720000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml), DMF or chloroform. Slightly soluble in ethanol (1mg/ml) methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | TYZROVQLWOKYKF-ZDUSSCGKSA-N |
| Smiles | CC(NC[C@H]1CN(C2=CC=C(N3CCOCC3)C(F)=C2)C(O1)=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4mg/ml). Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes and preventing the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.
Product References
(1) C.W. Ford, et al.; Antimicrob. Agents Chemother. 40, 1508 (1996) | (2) S.J. Brickner, et al.; J. Med. Chem. 39, 673 (1996) | (3) R.N. Jones, et al.; Antimicrob. Agents Chemother. 40, 720 (1996) | (4) D. Clemett & A. Markham; Drugs 59, 815 (2000) (Review) | (5) H.B. Fung, et al.; Clin. Ther. 23, 356 (2001) (Review) | (6) C.W. Ford, et al.; Curr. Drug Targets Infect. Disord. 1, 181 (2001) (Review) | (7) D.M. Livermore; J. Antimicrob. Chemother. 51, ii9 (2003) (Review) | (8) S.J. Brickner, et al.; J. Med. Chem. 51, 1981 (2008) (Review) | (9) K.L. Leach, et al.; Ann. N. Y. Acad. Sci. 1222, 49 (2011) (Review) | (10) S. Ager & K. Gould; Infect. Drug Resist. 5, 87 (2012) | (11) B.A. Diep, et al.; Curr. Ther. Res. Clin. Exp. 73, 86 (2012) (Review) | (12) L.A. Pauchard, et al.; PLoS One 12, e0187187 (2017)