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Chemodex
Levocetirizine dihydrochloride
49
CHF
CHF 49.00
In stock
CDX-L0121-M01010 mgCHF 49.00
CDX-L0121-M05050 mgCHF 189.00
| Product Details | |
|---|---|
| Synonyms | (R)-Cetirizine dihydrochloride; (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H25ClN2O3 . 2HCl |
| MW | 461.81 |
| CAS | 130018-87-0 |
| RTECS | AG0990000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in water (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PGLIUCLTXOYQMV-GHVWMZMZSA-N |
| Smiles | ClC(C=C1)=CC=C1[C@@H](C2=CC=CC=C2)[NH+]3CC[NH+](CCOCC(O)=O)CC3.[Cl-].[Cl-] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
Product References
(1) M. Gillard, et al.; Inflamm. Res. 52, S49 (2003) | (2) L. Zhang, et al.; Pharmacol. 92, 14 (2013) | (3) C. Kitayama-Sugiyama, et al.; Immunotoxicol. 35, 545 (2013) | (4) A. Kanei, et al.; In Vivo 28, 657 (2014)