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Chemodex
Litihium Ionophore III
Product Details | |
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Synonyms | ETH 1810; N,N-Dicyclohexyl-N',N'-diisobutyl-cis-cyclohexane-1,2-dicarboxamide |
Product Type | Chemical |
Properties | |
Formula |
C28H50N2O2 |
MW | 446.71 |
CAS | 99281-50-2 |
Source/Host Chemicals | Synthetic |
Purity Chemicals | ≥98% (HPLC) |
Appearance | White powder. |
Solubility | Soluble in chlorofrom or DCM. |
Identity | Determined by 1H-NMR. |
Declaration | Manufactured by Chemodex. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
InChi Key | QGKITQHJONXIQV-IZZNHLLZSA-N |
Smiles | O=C(N(C1CCCCC1)C2CCCCC2)[C@H]3[C@@H](C(N(CC(C)C)CC(C)C)=O)CCCC3 |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Lithium ionophore III (ETH 1810) has been used in liquid membrane electrodes for the determination of Li concentration in blood. It is a neutral non-cyclic Li(+)-selective ionophore, which can transport lithium and other monovalent cations, across lipid bilayer membranes, forming 2:1 ionophore:ion membrane-permeating species. The selectivity is Li+ > Na+ > K+ > Cs+. ETH 1810 was also found to be capable of acting as a carrier of biogenic amines and related molecules, with the following selectivity sequence: Tryptamine > Phenylethylamine > Tyramine > Serotonin > Li+ > NH+4 > Dopamine. Protons at physiological concentrations do not interfere with the lithium transport.
(1) E. Metzger et al. Anal. Chem. 59, 1600, (1987) | (2) A. Zeevi & R. Margalit; J. Membr. Biol. 121, 133 (1991) | (3) A. Zeevi & R. Margalit; Arch. Biochem. Biophys. 298, 84 (1992) | (4) E. Bakker & E. Pretsch; Anal. Chem. 70, 295 (1998)