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Chemodex
Lupeol
81
CHF
CHF 81.00
In stock
CDX-L0128-M02525 mgCHF 81.00
CDX-L0128-M100100 mgCHF 244.00
| Product Details | |
|---|---|
| Synonyms | β-Viscol; 20(29)-Lupen-3β-ol; 3β-Hydroxy-20(29)-lupene; Clerodol; Fagarasterol; Lupenol; Monogynol B; NSC 90487 |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H50O |
| MW | 426.72 |
| CAS | 545-47-1 |
| RTECS | OK5763000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White Powder. |
| Solubility | Soluble in DMSO (1mg/ml), DMF (1mg/ml) or ethanol (1mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | MQYXUWHLBZFQQO-QGTGJCAVSA-N |
| Smiles | C[C@@]12CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@@]1([H])[C@H](C(C)=C)CC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Lupeol, is a dietary triterpene found in certain fruits, vegetables, and medicinal plants. Lupeol has been shown tohave a broad range of activities, including antioxidant, anti-inflammatory, anticancer, antihyperglycemic, antidyslipidemic, antimutagenic, anti-diabetic, anti-asthma, antiprotozoal, antimicrobial, cardioprotective, hepatoprotective, nephroprotective and neuroprotective properties. It is a multi-target agent targeting proteins such as α-glucosidase, α-amylase, protein tyrosine phosphatase 1B (PTP 1B) and TCA cycle enzymes and targeting pathways such as IL-1 receptor-associated kinase-mediated toll-like receptor 4 (IRAK-TLR4), Bcl-2 family, nuclear factor kappa B (NF-κ), phosphatidylinositol-3-kinase (PI3-K)/Akt and Wnt/β-catenin signaling pathways.
Product References
(1) S. Sunitha, et al.; Fitoterapia 72, 516 (2001) | (2) M.A. Fernandez, et al.; J. Pharm. Pharmacol. 53, 1533 (2001) | (3) Y.J. You, et al.; Phytother. Res. 17, 341 (2003) | (4) M. Saleem, e al.; Oncogene 23, 5203 (2004) | (5) J. Fotie, et al.; J. Nat. Prod. 69, 62 (2006) | (6) M. Saleem, et al.; Clin. Cancer Res. 14, 2119 (2008) | (7) M. Saleem, et al.; Carcinogenesis 30, 808 (2009) | (8) K. Papi Reddy, et al.; Bioorg. Med. Chem. Lett. 19, 4463 (2009) | (9) R.S. Tarapore, et al.; Carcinogenesis 31, 1844 (2010) | (10) H.R. Siddique, et al.; Clin. Cancer Res. 17, 5379 (2011) | (11) H.R. Siddique & M. Saleem; Life Sci. 88, 285 (2011) (Review) | (12) F.S. Tsai, et al.; Adv. Exp. Med. Biol. 929, 145 (2016) (Review) | (13) V.R. Machado, et al.; Nat. Prod. Res. 32, 275 (2018) | (14) A. Malik, et al.; Drug Des. Devel. Ther. 13, 1501 (2019)