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Chemodex
Lycorine hydrochloride
170
CHF
CHF 170.00
In stock
CDX-L0129-M02020 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | Lycorine chloride |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H17NO4 . HCl |
| MW | 323.77 |
| CAS | 2188-68-3 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (15mg/mL), DMSO or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VUVNTYCHKZBOMV-NVJKKXITSA-N |
| Smiles | O[C@H]([C@H]1O)C=C2CCN3CC4=CC5=C(OCO5)C=C4[C@@]1([H])[C@]32[H].Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Lycorine is an active alkaloid abundant in Amaryllidaceae with a wide range of biological properties, including antifungal, antiparasitic, antiviral, anti-inflammatory and anticancer activity. It is a protein synthesis by preventing amino acid incorporation into proteins, potentially through the inhibition of peptidyltransferases. Lycorine induces cell cycle arrest and cell death in Trichomonas vaginalis. As anticancer agent on a molecular basis it induces G0/G1 phase cell cycle arrest and apoptosis, inhibits activity of histone deacetylases (HDACs), upregulates expression of p53 and p21, downregulates expression of cyclin D1 and CDK4, inhibits the Wnt/β-catenin pathway, activates ROCK1and inhibits JAK/STAT pathways. Lycorine exhibits antiviral activities against enterovirus, flaviviruses, Zika virus, HIV-1, SARS-CoV, SARS-CoV-2 and hepatitis C virus, most probably by suppressing viral replication. Lycorine has been shown to inhibit NLRP3 inflammasome activation and pyroptosis.
Product References
(1) M. Kukhanova, et al.; FEBS Lett. 160, 129 (1983) | (2) R.B. Giordani, et al.; Phytochemistry 72, 645 (2011) | (3) L. Li, et al.; Cancer Cell Int. 12, 49 (2012) | (4) Z. Cao, et al.; Toxicol. Lett. 218, 174 (2013) | (5) J.W. Shen, et al.; J. Microbiol. Biotechnol. 24, 354 (2014) | (6) S. Wu, et al.; Front. Pharmacol. 9, 881 (2018) | (7) M. Roy, et al.; Biomed. Pharmacother. 107, 615 (2018) | (8) W.Y. Liu, et al.; Front. Pharmacol. 10, 651 (2019) | (9) H. Hu, et al.; Onco. Targets Ther. 12, 5377 (2019) | (10) H. Wang, et al.; Br. J. Haematol. 189, 1151 (2020) | (11) Q. Liang, et al.; Pharmacol. Res. 158, 104884 (2020) | (12) H. Chen, et al.; Virology 546, 88 (2020) | (13) Y.N. Zhang, et al.; Emerg. Microbes Infect. 9, 1170 (2020)