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Chemodex
Lovastatin
88
CHF
CHF 88.00
In stock
CDX-L0281-M02525 mgCHF 88.00
CDX-L0281-M100100 mgCHF 299.00
| Product Details | |
|---|---|
| Synonyms | Mevilonin; MK-803; 6-α-Methylcompactin; BRN 3631989 |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H36O5 |
| MW | 404.54 |
| CAS | 75330-75-5 |
| RTECS | EK7907000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in DMSO (20mg/ml), DMF (15mg/ml) or ethanol (20mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
| Smiles | C[C@H]1C=CC2=C[C@H](C)C[C@H](OC([C@@H](C)CC)=O)[C@]2([H])[C@H]1CC[C@H]3OC(C[C@H](O)C3)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. Lovastatin is a prodrug, which is hydrolyzed in vivo to the active β-hydroxy acid open ring form. Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA. Lovastatin is an effective anti-hypercholesterolemic agent widely used as a lipid-lowering drug. In addition to lowering blood lipid levels, Lovastatin also has been shown to have anticancer, neuroprotective, anti-inflammatory, antiviral and antibacterial properties.
Product References
(1) A.W. Alberts, et al.; PNAS 77, 3957 (1980) | (2) M. Jakobisiak, et al.; PNAS 88, 3628 (1991) | (3) P. Negre-Aminou, et al.; Biochim. Biophys. Acta 1345, 259 (1997) | (4) B. Kwak, et al.; Nat. Med. 6, 1399 (2000) | (5) C. Wojcik, et al.; Int. J. Biochem. Cell Biol. 32, 957 (2000) | (6) L.J. Raggatt & N.C. Partridge; Drugs 62, 2185 (2002) (Review) | (7) W.W. Wong, et al.; Leukemia 16, 508 (2002) | (8) K.K. Chan, et al.; Clin. Cancer Res. 9,10 (2003) | (9) L.M. Blanco-Colio, et al.; Kidney Int. 63, 12 (2003) | (10) J.A. Tobert; Nat. Rev. Drug Discov. 2, 517 (2003) (Review) | (11) V. Chopra, et al.; Cardiovasc. Drugs Ther. 21, 161 (2007) | (12) Z. Xiong, et al.; Food Chem. Toxicol. 131, 110585 (2019) (Review)