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Chemodex
4-Methylumbelliferone
41
CHF
CHF 41.00
In stock
CDX-M0007-G02525 gCHF 41.00
CDX-M0007-G100100 gCHF 88.00
| Product Details | |
|---|---|
| Synonyms | β-Methylumbelliferone; 4-MU; 7-Hydroxy-4-methylcoumarin; 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one; 7-Hydroxy-4-methyl-2-chromenone; NSC 19026; NSC 9408; Omega 127; Pilot 447 |
| Product Type | Chemical |
| Properties | |
| Formula | C10H8O3 |
| MW | 176.17 |
| CAS | 90-33-5 |
| RTECS | GN7000000 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Beige powder. |
| Solubility | Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or methanol (20mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HSHNITRMYYLLCV-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2C(OC(C=C2C)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer.
Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: λex=360nm; λem=448nm; pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity.
Product References
(1) R.F. Chen; Anal. Lett. 1, 423 (1968) | (2) T. Nakamura, et al.; Biochem. Mol. Biol. Int. 43, 263 (1997) | (3) I. Jones, et al.; Mol. Gen. Metab. 108, S51 (2003) | (4) I. Kakizaki, et al.; J. Biol. Chem. 279, 33281 (2004) | (5) S. Yoshihara, et al.; FEBS Lett. 579, 2722 (2005) | (6) R. Nakamura, et al.; Cell Biol. Int. 31, 1022 (2007) | (7) D. Vigetti, et al.; Glycobiology 19, 537 (2009) | (8) A. Kultti, et al.; Exp. Cell Res. 315, 1914 (2009) | (9) H. Urakawa, et al.; Int. J. Cancer 130, 454 (2012) | (10) J.A. Garcia-Vilas, et al.; J. Agric. Food Chem. 61, 4063 (2013) | (11) H. Zhi, et al.; J. Spectrosc. 2013, ID 147128 (2013) | (12) N. Nagy, et al.; Front. Immunol. 6, 123 (2015) (Review) | (13) H. Ban, et al.; Anticancer Res. 35, 5231 (2015)