4-Methylumbelliferyl β-D-glucuronide dihydrate

Specifications / Handling

More Information
Product Details
Synonyms	4-Methylumbelliferyl-ß-D-glucopyranosiduronic acid; MUG; 4-MUG; 4-MU-glcUA; MUGlcU
Product Type	Chemical
Properties
Formula	C₁₆H₁₆O₉ . xH₂O
MW	352.29
CAS	881005-91-0 \| 6160-80-1 (anhydrous)
Purity Chemicals	≥99% (HPLC)
Appearance	Colourless to white crystalline powder.
Solubility	Soluble in DMSO (50mg/ml) or water.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	ARQXEQLMMNGFDU-JHZZJYKESA-N
Smiles	O[C@@H]1[C@@H](O)[C@H](O)[C@@H](C(O)=O)O[C@H]1OC2=CC(OC(C=C3C)=O)=C3C=C2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

4-Methylumbelliferyl-β-D-glucuronic acid dihydrate (MUG) is a non-fluorescent but fluorogenic β-glucuronidase substrate. Once cleaved, MUG yields blue fluorescence seen under UV light. The substrate is commonly used for rapid sensitive identification of Escherichia coli contamination and for detecting marker GUS gene expression in plants with high sensitivity. In microbiology it is a component in Violet Red Bile Agar and Lauryl Tryptose Broth, for the detection of coliform organisms in water, food and dairy products. Spectral Data. λEx/λEm= 360/450 nm (cleaved product). MUG both directly and indirectly inhibits hyaluronan (HA) synthesis.

Product References

(1) P.C. Feng & P.A. Hartman; Appl. Environ. Microbiol. 43, 1320 (1982) | (2) B. Sperker, et al.; J. Chromatogr. B Biomed. Sci. Appl. 685, 181 (1996) | (3) P. Villari, et al.; Lett. Appl. Microbiol. 24, 286 (1997) | (4) S. Fior, et al.; Plant Sci. 176, 130 (2009) | (5) N. Nagy, et al.; JBC 294, 7864 (2019)

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