Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Micafungin sodium
75
CHF
CHF 75.00
In stock
CDX-M0187-M0055 mgCHF 75.00
CDX-M0187-M02525 mgCHF 299.00
| Product Details | |
|---|---|
| Synonyms | Mycamine; Funguard; FK463; 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 sodium salt |
| Product Type | Chemical |
| Properties | |
| Formula | C56H70N9NaO23S |
| MW | 1292.26 |
| CAS | 208538-73-2 |
| RTECS | TP7846500 |
| Source/Host Chemicals | Semisynthetic |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to beige powder. |
| Solubility | Soluble in DMSO or DMF (both 10mg/ml). Slightly soluble in ethanol, methanol or water (all 1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KOOAFHGJVIVFMZ-WZPXRXMFSA-M |
| Smiles | O[C@@H]([C@@H](C)C1)[C@@H](C(N[C@@H]([C@@H](C2)O)O)=O)N1C([C@H]([C@@H](CC(N)=O)O)NC([C@H]([C@@H]([C@H](C(C=C3)=CC(OS([O-])(=O)=O)=C3O)O)O)NC([C@H](C[C@H]4O)N(C4)C([C@H]([C@@H](C)O)NC([C@H]2NC(C(C=C5)=CC=C5C6=NOC(C(C=C7)=CC=C7OCCCCC)=C6)=O)=O)=O)=O)=O)=O.[Na+] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Micafungin is a semisynthetic echinocandin antifungal. Micafungin inhibits the enzyme β(1,3)-D-Glucan synthase, consequently 1,3-β-D-glucan synthesis and thereby disturbing the integrity of the fungal cell wall. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp. The target enzyme does not exist in mammalian systems.
Product References
(1) M. Tomishima, et al.; J. Antibiot. 52, 674 (1999) | (2) R.A. Fromtling; Drugs Today 38, 245 (2002) (Review) | (3) A.J. Carillo-Munoz, et al.; Rev. Esp. Quimioter. 19, 130 (2006) | (4) J.J. Vehreschild & O.A. Cornely; Future Microbiol. 1, 161 (2006) | (5) J.M. Joseph, et al.; Pharmacotherapy 27, 53 (2007) (Review) | (6) N.P. Wiederhold & J.S. Lewis; Expert Opin. Pharmacother. 8, 1155 (2007) (Review) | (7) A.M. Bormann & V.A. Morrison; Drug. Des. Devel. Ther. 3, 295 (2009)