|Synonyms||Naprosyn; Equiproxen; Laraflex; (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid|
|Purity Chemicals||≥98% (HPLC)|
|Solubility||Soluble in water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate or tetrahydrofuran.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).
(1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970) | (2) R.N. Brogden, et al.; Drugs 18, 241-277 (1979) | (3) W.F. Kean, et al.; J. Pharm. Sci. 78, 324 (1989) | (4) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010) | (5) T. Takeda, et al.; J. Phys. Chem. B. 114, 15394 (2010) | (6) F. Dimiza, et al.; J. Inorg. Biochem. 105, 476 (2011)