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Chemodex
Nordihydroguaiaretic acid
As low as
64
CHF
CHF 64.00
In stock
Only %1 left
CDX-N0178-G0011 gCHF 64.00
CDX-N0178-G0055 gCHF 258.00
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| Product Details | |
|---|---|
| Synonyms | NDGA; Dihydronorguaiaretic acid; NSC 4291; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane |
| Product Type | Chemical |
| Properties | |
| Formula | C18H22O4 |
| MW | 302.37 |
| CAS | 500-38-9 |
| RTECS | UX1750000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to light beige powder or crystals. |
| Solubility | Soluble in DMSO or ethanol (both 100mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HCZKYJDFEPMADG-UHFFFAOYSA-N |
| Smiles | C(C(C(CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Nordihydroguaiaretic acid (NDGA) is a potent free radical scavenger, protecting cells and tissues from oxidative stress. It is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. It is an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases. NDGA inhibits p300 and activates autophagy. This compound shows antioxidant, antimutagenic, anticancer, antiviral and anti-inflammatory characteristics mediated through multiple signaling pathways.
Product References
(1) T. Nakadate, et al.; Gan 73, 841 (1982) | (2) S.J. Korn & R. Horn; Mol. Pharmacol. 38, 524 (1990) | (3) Z.Y. Wang, et al.; Mutat. Res. 261, 153 (1991) | (4) M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) | (5) R.W. McDonald, et al.; Anticancer Drug Des. 16, 261 (2001) | (6) T. Seufferlein, et al.; Br. J. Cancer. 86, 1188 (2002) | (7) C.H. Lee, et al.; Exp. Cell Res. 289, 335 (2003) | (8) E. Floriano-Sanchez, et al.; Free Radic. Res. 40, 523 (2006) | (9) M. Zavodovskaya, et al.; J. Cell Biochem. 103, 624 (2008) | (10) Q. Chen; Curr. Top. Med. Chem. 9, 1636 (2009) (Review) | (11) J.M. Lu, et al.; Med. Sci. Monit. 16, RA93 (2010) (Review) | (12) T. Tezil, et al.; NPJ Aging Mech. Dis. 5, 7 (2019) | (13) G. Manda, et al.; Front. Pharmacol. 11, 151 (2020) | (14) F. Martinez, et al.; Phytomedicine 106, 154424 (2022)