Chemodex

Nordihydroguaiaretic acid

Name: Nordihydroguaiaretic acid
Brand: Chemodex
SKU: CDX-N0178
Price: 64.00 CHF
Availability: InStock

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CDX-N0178-G0011 gCHF 64.00

CDX-N0178-G0055 gCHF 258.00

Specifications / Handling

More Information
Product Details
Synonyms	NDGA; Dihydronorguaiaretic acid; NSC 4291; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
Product Type	Chemical
Properties
Formula	C₁₈H₂₂O₄
MW	302.37
CAS	500-38-9
RTECS	UX1750000
Source/Host Chemicals	Synthetic
Purity Chemicals	≥97% (HPLC)
Appearance	White to light beige powder or crystals.
Solubility	Soluble in DMSO or ethanol (both 100mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturer's product datasheet.
InChi Key	HCZKYJDFEPMADG-UHFFFAOYSA-N
Smiles	C(C(C(CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Nordihydroguaiaretic acid (NDGA) is a potent free radical scavenger, protecting cells and tissues from oxidative stress. It is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. It is an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases. NDGA inhibits p300 and activates autophagy. This compound shows antioxidant, antimutagenic, anticancer, antiviral and anti-inflammatory characteristics mediated through multiple signaling pathways.

Product-specific References

(1) T. Nakadate, et al.; Gan 73, 841 (1982) | (2) S.J. Korn & R. Horn; Mol. Pharmacol. 38, 524 (1990) | (3) Z.Y. Wang, et al.; Mutat. Res. 261, 153 (1991) | (4) M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) | (5) R.W. McDonald, et al.; Anticancer Drug Des. 16, 261 (2001) | (6) T. Seufferlein, et al.; Br. J. Cancer. 86, 1188 (2002) | (7) C.H. Lee, et al.; Exp. Cell Res. 289, 335 (2003) | (8) E. Floriano-Sanchez, et al.; Free Radic. Res. 40, 523 (2006) | (9) M. Zavodovskaya, et al.; J. Cell Biochem. 103, 624 (2008) | (10) Q. Chen; Curr. Top. Med. Chem. 9, 1636 (2009) (Review) | (11) J.M. Lu, et al.; Med. Sci. Monit. 16, RA93 (2010) (Review) | (12) T. Tezil, et al.; NPJ Aging Mech. Dis. 5, 7 (2019) | (13) G. Manda, et al.; Front. Pharmacol. 11, 151 (2020) | (14) F. Martinez, et al.; Phytomedicine 106, 154424 (2022)

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