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Chemodex
Naphthol AS-BI phosphate disodium salt hydrate
193
CHF
CHF 193.00
In stock
CDX-N0244-G0011 gCHF 193.00
CDX-N0244-G0055 gCHF 670.00
| Product Details | |
|---|---|
| Synonyms | 2-Naphthalenecarboxamide; 7-Bromo-N-(2-methoxyphenyl)-3-(phosphonooxy)-, disodium salt hydrate |
| Product Type | Chemical |
| Properties | |
| Formula | C18H13BrNNa2O6P . xH2O |
| MW | 496.16 (anhydrous basis) |
| CAS | 207569-04-8 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (50mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | WNPKMQCBZKBNOS-UHFFFAOYSA-L |
| Smiles | BrC1=CC=C(C=C(OP([O-])([O-])=O)C(C(NC2=C(OC)C=CC=C2)=O)=C3)C3=C1.O.[Na+].[Na+] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Very hygroscopic. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Naphthol AS-BI-phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-BI-phosphate is converted to naphthol AS-BI (N-ASBI) displaying excitation/emission spectra of 405/515nm. N-ASBI fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations.
Product References
(1) V. Maggi & W.L. Chng; Histochemie 7, 267 (1966) | (2) A. Vaughan, et al.; Anal. Chem. 43, 721 (1971) | (3) L.T. Yam; Am. J. Med. 56, 604 (1974) | (4) L. Bell & L. Williams; Histochemistry 60, 85 (1979) | (5) F. Dolbeare & W. Phares; J. Histochem. Cytochem. 27, 120 (1979) | (6) F. Dolbeare; J. Histochem. Cytochem. 27, 1644 (1979) | (7) P.J. Stoward, et al.; Histochemistry 74, 367 (1982) | (8) M. Kimura & I. Ichihara; Histochemistry 82, 519 (1985) | (9) R. Gillitzer, et al.; J. Histochem. Cytochem. 38, 307 (1990) | (10) A.J. Janckila, et al.; J. Bone Miner. Res. 16, 788 (2001) | (11) S.C. Rodig; Cold Spring Harb. Protoc. (2019)